Universität zu Köln

Weber, Christina, Krug, Oliver, Kamber, Matthias and Thevis, Mario (2017). Qualitative and Semiquantitative Analysis of Doping Products Seized at the Swiss Border. Subst. Use Misuse, 52 (6). S. 742 - 754. PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 1532-2491

Full text not available from this repository.

Abstract

Background: Substances developed for therapeutic use are also known to be misused by athletes as doping agents and, outside of regulated sport, for image-enhancement. This has generated a market for counterfeit doping substances. Counterfeit doping agents may be of poor pharmaceutical quality and therefore constitute health risks to consumers. Objectives: This study aims to investigate the pharmaceutical quality of 1,190 doping products seized at the Swiss border. Methods: Swiss customs authorities seize incoming shipments potentially containing doping agents. Qualitative and semiquantitative analyses were performed in order to test for prohibited doping substances. The main analytical methods utilized for characterizing confiscated compounds were liquid chromatography-high resolution mass spectrometry, polyacrylamide gel electrophoresis with subsequent in-gel tryptic digestion and identification of peptidic compounds using nanoliquid chromatography-tandem mass spectrometry, and electrochemiluminescence immuno assay. Results: For 889 (75%) of the analyzed products, the label suggested the content of anabolic agents, for 146 samples (12%) peptide hormones or growth factors, and for 113 items (9%) antiestrogens, aromatase inhibitors or other metabolic modulators. For the majority of the investigated products, the pharmaceutical quality was an unsatisfactory standard: nonapproved substances were detected and less than 20% of the products contained the claimed substance in the respective amount. Conclusion: A comprehensive sample of confiscated doping products was analyzed, allowing for monitoring of developments regarding the use of doping substances in Switzerland and for anticipating future trends and challenges in sports drug testing. An alarming number of tested products was of substandard pharmaceutical quality.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Weber, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Krug, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Kamber, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Thevis, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-246563
DOI:	10.1080/10826084.2016.1263665
Journal or Publication Title:	Subst. Use Misuse
Volume:	52
Number:	6
Page Range:	S. 742 - 754
Date:	2017
Publisher:	TAYLOR & FRANCIS INC
Place of Publication:	PHILADELPHIA
ISSN:	1532-2491
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PERFORMANCE-ENHANCING DRUGS; ANDROGENIC STEROID USE; BLACK-MARKET PRODUCTS; GROWTH-HORMONE; ANABOLIC-STEROIDS; TESTOSTERONE PREPARATIONS; IDENTIFICATION; SPORTS; AGENTS; SEIZURES Multiple languages Substance Abuse; Psychiatry; Psychology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24656