Universität zu Köln

Dolscheid-Pommerich, Ramona C., Manekeller, Steffen, Walgenbach-Bruenagel, Gisela, Kalff, Joerg C., Hartmann, Gunther ORCID: 0000-0003-1021-2018, Wagner, Birgit Stoffel and Holdenrieder, Stefan (2017). Clinical Performance of CEA, CA19-9, CA15-3, CA125 and AFP in Gastrointestinal Cancer Using LOCI (TM)-based Assays. Anticancer Res., 37 (1). S. 353 - 360. ATHENS: INT INST ANTICANCER RESEARCH. ISSN 1791-7530

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Abstract

Background/Aim: Few data are available regarding the clinical performance of LOCI (TM)-based tumor marker assays. We investigated the diagnostic power of carcinogenic antigen, carbohydrate antigen 19-9, carbohydrate antigen 15-3, carbohydrate antigen 125 and alpha-fetoprotein for detection of gastrointestinal (GI) cancer. Patients and Methods: We analyzed sera from 204 patients (107 with GI cancer, 73 with benign GI diseases and 24 healthy controls) using the Dimension (TM) Vista1500 analyzer. Results: Levels of biomarkers in healthy controls were in the expected ranges and were only slightly higher in benign GI controls. Established tumor-type-associated markers were elevated in specific cancer types and discriminated well between cancer and benign controls. Best performance was found for CEA in colorectal cancer (area under the curve=0.84, sensitivity=51.7% at 95% specificity vs. benign), CA19-9 in gallbladder/pancreatic cancer (AUC=0.85, sensitivity=60.6%) and AFP in liver cancer (AUC=0.87, sensitivity=68.4%). Conclusion: Our study demonstrated the high diagnostic power of well-known biomarkers. LOCI (TM)-based tumor marker assays give reliable results in routine diagnostics.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dolscheid-Pommerich, Ramona C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Manekeller, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Walgenbach-Bruenagel, Gisela UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalff, Joerg C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartmann, Gunther UNSPECIFIED orcid.org/0000-0003-1021-2018 UNSPECIFIED Wagner, Birgit Stoffel UNSPECIFIED UNSPECIFIED UNSPECIFIED Holdenrieder, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-247964
DOI:	10.21873/anticanres.11329
Journal or Publication Title:	Anticancer Res.
Volume:	37
Number:	1
Page Range:	S. 353 - 360
Date:	2017
Publisher:	INT INST ANTICANCER RESEARCH
Place of Publication:	ATHENS
ISSN:	1791-7530
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TUMOR-MARKERS; CARCINOEMBRYONIC ANTIGEN; ALTERNATIVE ANTIBODY; EUROPEAN MULTICENTER; PANCREATIC-CANCER; MONITOR ASSAY; CA-19-9; CYFRA21-1; SURVIVAL; STAGE Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24796