Universität zu Köln

Berger, Hanna, Wodarz, Andreas ORCID: 0000-0002-0007-6289 and Borchers, Annette (2017). PTK7 Faces the Wnt in Development and Disease. Front. Cell. Dev. Biol., 5. LAUSANNE: FRONTIERS MEDIA SA. ISSN 2296-634X

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Abstract

PTK7 (protein tyrosine kinase 7) is an evolutionarily conserved transmembrane receptor regulating various processes in embryonic development and tissue homeostasis. On a cellular level PTK7 affects the establishment of cell polarity, the regulation of cell movement and migration as well as cell invasion. The PTK7 receptor has been shown to interact with ligands, co-receptors, and intracellular transducers of Wnt signaling pathways, pointing to a function in the fine-tuning of the Wnt signaling network. Here we will review recent findings implicating PTK7 at the crossroads of Wnt signaling pathways in development and disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Berger, Hanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Wodarz, Andreas UNSPECIFIED orcid.org/0000-0002-0007-6289 UNSPECIFIED Borchers, Annette UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-248344
DOI:	10.3389/fcell.2017.00031
Journal or Publication Title:	Front. Cell. Dev. Biol.
Volume:	5
Date:	2017
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	2296-634X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PLANAR CELL POLARITY; NEURAL-TUBE DEFECTS; TYROSINE KINASE 7; CONVERGENT EXTENSION; PROTEIN; EXPRESSION; GENE; MORPHOGENESIS; ENDOCYTOSIS; MECHANISMS Multiple languages Cell Biology; Developmental Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24834