Universität zu Köln

Ammerpohl, Ole, Deckert, Martina and Montesinos-Rongen, Manuel (2016). The tumor epigenome - from gene regulation via tumor classification to therapy target. Med. Genet., 28 (4). S. 424 - 435. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1863-5490

Full text not available from this repository.

Abstract

Epigenetic control mechanisms are essential for the coordination of numerous cellular processes, including differentiation and development as well as for the adaptation of gene activity according to environmental conditions. In particular, tumor diseases are often accompanied by comprehensive alterations in the epigenome. These alterations are frequently characteristic either for the tumor entity, the tumor state, the clinical response of the tumor to an anti-cancer therapy or the individual prognosis of the patient. After a brief introduction into epigenetic marks and their impact for cancer, this article will focus on alterations in the tumor epigenome and their value for individualized medicine.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ammerpohl, Ole UNSPECIFIED UNSPECIFIED UNSPECIFIED Deckert, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Montesinos-Rongen, Manuel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-253436
DOI:	10.1007/s11825-016-0115-1
Journal or Publication Title:	Med. Genet.
Volume:	28
Number:	4
Page Range:	S. 424 - 435
Date:	2016
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1863-5490
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ISLAND METHYLATOR PHENOTYPE; DNA METHYLATION; HEMATOPOIETIC STEM; HISTONE VARIANTS; CANCER; MUTATION; GENOME; METHYLOME; CTCF; BURKITT Multiple languages Genetics & Heredity Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25343