Rabenstein, Monika, Vay, Sabine Ulrike, Flitsch, Lea Jessica, Fink, Gereon. Rudolf, Schroeter, Michael and Rueger, Maria Adele (2016). Osteopontin directly modulates cytokine expression of primary microglia and increases their survival. J. Neuroimmunol., 299. S. 130 - 139. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1872-8421

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Abstract

Osteopontin (OPN) is constitutively expressed in the brain and upregulated during neuroinflammation, e.g., focal cerebral ischemia. In OPN-deficient mice, microglia are deregulated after ischemia, but specific OPN-effects on microglia remain elusive. Primary microglia were cultured in the presence or absence of OPN. The survival of microglia under stress conditions was dose-dependently increased by OPN. Lipopolysaccharides (LPS)-induced release of nitric oxide (NO), TNF-alpha, and IL-6, as well as expression of inducible Nitric Oxide Synthase (iNOS), were attenuated by OPN. Data suggest that OPN modulates microglia function by shifting their inflammatory profile towards a neutral anti-inflammatory phenotype. (C) 2016 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Rabenstein, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vay, Sabine UlrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Flitsch, Lea JessicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, Gereon. RudolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schroeter, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rueger, Maria AdeleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-258354
DOI: 10.1016/j.jneuroim.2016.09.009
Journal or Publication Title: J. Neuroimmunol.
Volume: 299
Page Range: S. 130 - 139
Date: 2016
Publisher: ELSEVIER SCIENCE BV
Place of Publication: AMSTERDAM
ISSN: 1872-8421
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CENTRAL-NERVOUS-SYSTEM; MURINE MACROPHAGES; ISCHEMIC-STROKE; CELL-SURVIVAL; ACTIVATION; BRAIN; INJURY; INFLAMMATION; POLARIZATION; INTEGRINMultiple languages
Immunology; NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/25835

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