Universität zu Köln

Kallendrusch, Sonja, Schopow, Nikolas, Stadler, Sonja C., Buening, Hildegard and Hacker, Ulrich T. (2016). Adeno-Associated Viral Vectors Transduce Mature Human Adipocytes in Three-Dimensional Slice Cultures. Hum. Gene Ther. Methods, 27 (5). S. 171 - 174. NEW ROCHELLE: MARY ANN LIEBERT, INC. ISSN 1946-6544

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Abstract

Adipose tissue plays a pivotal role, both in the regulation of energy homeostasis and as an endocrine organ. Consequently, adipose tissue dysfunction is closely related to insulin resistance, morbid obesity, and metabolic syndrome. To study molecular mechanisms and to develop novel therapeutic strategies, techniques are required to genetically modify mature adipocytes. Here, we report on adeno-associated viral (AAV) vectors as a versatile tool to transduce human mature adipocytes in organotypic three-dimensional tissue cultures.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kallendrusch, Sonja UNSPECIFIED UNSPECIFIED UNSPECIFIED Schopow, Nikolas UNSPECIFIED UNSPECIFIED UNSPECIFIED Stadler, Sonja C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Buening, Hildegard UNSPECIFIED UNSPECIFIED UNSPECIFIED Hacker, Ulrich T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-259560
DOI:	10.1089/hgtb.2016.137
Journal or Publication Title:	Hum. Gene Ther. Methods
Volume:	27
Number:	5
Page Range:	S. 171 - 174
Date:	2016
Publisher:	MARY ANN LIEBERT, INC
Place of Publication:	NEW ROCHELLE
ISSN:	1946-6544
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ADIPOSE-TISSUE; GENE-TRANSFER; MICE Multiple languages Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25956