Universität zu Köln

Schaub, Friederike, Enders, Philip ORCID: 0000-0002-9527-4957, Zachewicz, Jonas, Heindl, Ludwig M., Stanzel, Tisha P., Cursiefen, Claus and Bachmann, Bjorn O. (2016). Impact of Donor Age on Descemet Membrane Endothelial Keratoplasty Outcome: Evaluation of Donors Aged 17-55 Years. Am. J. Ophthalmol., 170. S. 119 - 128. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1879-1891

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Abstract

PURPOSE: To investigate whether the impression held by Descemet membrane endothelial keratoplasty (DMEK) surgeons that young donors are less suitable for DMEK is reflected in 1-year postoperative results. DESIGN: Retrospective, comparative, interventional case series. METHODS: Records of 1084 consecutive DMEKs were reviewed and matched with corresponding donor tissue data. Young donors (aged <= 55 years; subgroups: 10-40, 41-55) were compared with old donors (> 55 years; subgroups: 56-65, > 65). Outcome measures in DMEK recipients included best spectacle-corrected visual acuity (BSCVA), endothelial cell density (ECD), central corneal thickness (CCT) at 6 and 12 months, and rebubbling rate. RESULTS: Out of 529 included DMEKs, 94 (17.8%) were performed with young donor lamellae (mean donor age 49.31 +/- 6.35 years; range: 17-55 years) and 435 (82.2%) with older donor tissue (mean age 70.68 +/- 7.77 years; range: 56-90 years). Postoperative BSCVA, ECD, and CCT results were comparable in both groups at 6 and 12 months without statistically significant differences. Overall rebubbling rate in the young donor group was 42.6% and in the old donors was 53.3% (P = .058). Complication rates also did not differ significantly. CONCLUSION: Younger donor age seems not to affect the clinical outcome of DMEK surgery negatively within the first postoperative year, suggesting donor corneas with donor age down to 17 years as safe donor tissue for DMEK surgery. (C) 2016 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schaub, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Enders, Philip UNSPECIFIED orcid.org/0000-0002-9527-4957 UNSPECIFIED Zachewicz, Jonas UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stanzel, Tisha P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Bachmann, Bjorn O. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-260337
DOI:	10.1016/j.ajo.2016.08.005
Journal or Publication Title:	Am. J. Ophthalmol.
Volume:	170
Page Range:	S. 119 - 128
Date:	2016
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1879-1891
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSTERIOR LAMELLAR KERATOPLASTY; SPLIT-CORNEA TRANSPLANTATION; TISSUE-PREPARATION; DMEK; COMPLICATIONS; TIME Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26033