Abbas, Yasmine, Azzazy, Hassan M. E., Tammam, Salma, Lamprecht, Alf, Ali, Mohamed Ehab, Schmidt, Annette ORCID: 0000-0002-7284-7847, Sollazzo, Silvio and Mathur, Sanjay (2016). Development of an inhalable, stimuli-responsive particulate system for delivery to deep lung tissue. Colloid Surf. B-Biointerfaces, 146. S. 19 - 31. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1873-4367

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Abstract

Lung cancer, the deadliest solid tumor among all types of cancer, remains difficult to treat. This is a result of unavoidable exposure to carcinogens, poor diagnosis, the lack of targeted drug delivery platforms and limitations associated with delivery of drug to deep lung tissues. Development of a non-invasive, patient-convenient formula for the targeted delivery of chemotherapeutics to cancer in deep lung tissue is the aim of this study. The formulation consisted of inhalable polyvinylpyrrolidone (PVP)/maltodextrin (MD)-based microparticles (MPs) encapsulating chitosan (CS) nanoparticles (NPs) loaded with either drug only or drug and magnetic nanoparticles (MNPs). Drug release from CS NPs was enhanced with the aid of MNP5 by a factor of 1.7 in response to external magnetic field. Preferential toxicity by CS NPs was shown towards tumor cells (A549) in comparison to cultured fibroblasts (L929). The prepared spray freeze dried (SFD) powders for CS NPs and CS MNP5 were of the same size at similar to 6 mu m. They had a fine particle fraction (FPF <= 5.2 (mu m)) of 40-42% w/w and mass median aerodynamic diameter (MMAD) of 5-6 mu m as determined by the Next Generation Impactor (NGI). SFD-MPs of CS MNPs possess higher MMAD due to the high density associated with encapsulated MNPs. The developed formulation demonstrates several capabilities including tissue targeting, controlled drug release, and the possible imaging and diagnostic values (due to its MNP5 content) and therefore represents an improved therapeutic platform for drug delivery to cancer in deep lung tissue. (C) 2016 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Abbas, YasmineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Azzazy, Hassan M. E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tammam, SalmaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lamprecht, AlfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ali, Mohamed EhabUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, AnnetteUNSPECIFIEDorcid.org/0000-0002-7284-7847UNSPECIFIED
Sollazzo, SilvioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mathur, SanjayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-261398
DOI: 10.1016/j.colsurfb.2016.05.031
Journal or Publication Title: Colloid Surf. B-Biointerfaces
Volume: 146
Page Range: S. 19 - 31
Date: 2016
Publisher: ELSEVIER SCIENCE BV
Place of Publication: AMSTERDAM
ISSN: 1873-4367
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
WHEAT-GERM-AGGLUTININ; DRUG-DELIVERY; CHITOSAN NANOPARTICLES; SUSTAINED-RELEASE; MULTIFUNCTIONAL NANOPARTICLES; SOLID TUMORS; CANCER; THERAPY; SURFACE; CHEMOTHERAPYMultiple languages
Biophysics; Chemistry, Physical; Materials Science, BiomaterialsMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/26139

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