Universität zu Köln

Friman, Vanda, Winqvist, Ola, Blimark, Cecilie, Langerbeins, Petra, Chapel, Helen and Dhalla, Fatima ORCID: 0000-0001-9244-2284 (2016). Secondary immunodeficiency in lymphoproliferative malignancies. Hematol. Oncol., 34 (3). S. 121 - 133. HOBOKEN: WILEY. ISSN 1099-1069

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Abstract

Secondary immunodeficiencies occur as a consequence of various diseases, including hematological malignancies, and the use of pharmacological therapies, such as immunosuppressive, anti-inflammatory, and biological drugs. Infections are the main cause of morbidity and mortality in multiple myeloma (MM) and chronic lymphocytic leukemia (CLL) patients. Recent advances in treatment have prolonged the duration of remission and the time between relapse phases in MM and CLL patients. However, managing multiple relapses and the use of salvage therapies can lead to cumulative immunosuppression and a higher risk of infections. The pathogenesis of immune deficiency secondary to lymphoproliferative malignancy is multifactorial including disease-and treatment-related factors. Supportive treatment, including early vaccination, anti-infective prophylaxis, and replacement immunoglobulin, plays a key role in preventing infections in MM and CLL. This article provides an overview of the basic immunology necessary to understand the pathogenesis of secondary immunodeficiency and the infectious complications in MM and CLL. We also discuss the evidence supporting the role of prophylactic replacement immunoglobulin treatment in patients with antibody failure secondary to MM and CLL and the indications for its use. Copyright (C) 2016 John Wiley & Sons, Ltd.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Friman, Vanda UNSPECIFIED UNSPECIFIED UNSPECIFIED Winqvist, Ola UNSPECIFIED UNSPECIFIED UNSPECIFIED Blimark, Cecilie UNSPECIFIED UNSPECIFIED UNSPECIFIED Langerbeins, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED Chapel, Helen UNSPECIFIED UNSPECIFIED UNSPECIFIED Dhalla, Fatima UNSPECIFIED orcid.org/0000-0001-9244-2284 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-263207
DOI:	10.1002/hon.2323
Journal or Publication Title:	Hematol. Oncol.
Volume:	34
Number:	3
Page Range:	S. 121 - 133
Date:	2016
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1099-1069
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHRONIC LYMPHOCYTIC-LEUKEMIA; IMMUNOGLOBULIN REPLACEMENT THERAPY; FLUDARABINE PLUS CYCLOPHOSPHAMIDE; INFLUENZAE TYPE-B; MULTIPLE-MYELOMA; MONOCLONAL GAMMOPATHY; INTRAVENOUS IMMUNOGLOBULIN; UNDETERMINED SIGNIFICANCE; PATHOGEN RECOGNITION; RANDOMIZED-TRIAL Multiple languages Oncology; Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26320