Budjan, Johannes, Benck, Urs, Lammert, Alexander, Ong, Melissa M., Mircheva, Miryana, Diehl, Steffen, Konstandin, Simon, Schad, Lothar R., Kraemer, Bernhard K., Schoenberg, Stefan O. and Haneder, Stefan (2016). Renal Denervation in Patients with Resistant Hypertension-Assessment by 3T Renal Na-23-MRI: Preliminary Results. In Vivo, 30 (5). S. 657 - 663. ATHENS: INT INST ANTICANCER RESEARCH. ISSN 1791-7549

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Abstract

Background/Aim: Renal denervation (RDN) has been considered a promising therapy option for patients suffering from therapy-resistant hypertension. Besides, in blood-pressure regularization, the kidneys play a fundamental role in sodium (Na-23) homeostasis. This study assesses the effect of RDN on renal Na-23 concentration using Na-23 magnetic resonance imaging (MRI). Patients and Methods: Two patients with therapy-resistant hypertension underwent RDN. Na-23-MRI, H-1-MRI, including diffusion weighted imaging (DWI), as well as endothelial dysfunction assessment, were performed 1 day prior, as well as 1, 30 and 90 days after RDN. Results: The renal corticomedullary Na-23 gradient did not change after RDN for all time points. Additionally, functional imaging and retinal vessel parameters were not influenced by RDN. Results regarding blood pressure changes and arterial stiffness, as well as patients' clinical outcome, were heterogeneous. Conclusion: RDN does not seem to alter renal Na-23 concentration gradients, as measured by MRI.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Budjan, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benck, UrsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lammert, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ong, Melissa M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mircheva, MiryanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diehl, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Konstandin, SimonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schad, Lothar R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kraemer, Bernhard K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schoenberg, Stefan O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haneder, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-263864
Journal or Publication Title: In Vivo
Volume: 30
Number: 5
Page Range: S. 657 - 663
Date: 2016
Publisher: INT INST ANTICANCER RESEARCH
Place of Publication: ATHENS
ISSN: 1791-7549
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ARTERIAL STIFFNESS; SODIUM-MRI; SYMPATHETIC DENERVATION; HUMAN KIDNEYS; RISKMultiple languages
Medicine, Research & ExperimentalMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/26386

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