Universität zu Köln

Ensenauer, R., Hucklenbruch-Rother, E., Bruell, V. and Doetsch, J. (2016). Perinatal programming of type 2 diabetes mellitus. Diabetologe, 12 (6). S. 437 - 449. NEW YORK: SPRINGER. ISSN 1860-9724

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Abstract

Early metabolic influences in utero increase the risk for metabolic imbalances such as type 2 diabetes mellitus in the offspring's later life, via mechanisms referred to as fetal programming. Important perinatal risk factors for metabolic alterations in later life are intrauterine growth restriction, preconception maternal obesity, and a diabetic intrauterine milieu. As shown in human studies and experimental animal models, maternal diabetes mellitus in pregnancy can induce various long-term consequences for organ function in the offspring. Underlying mechanisms of perinatal programming involve epigenetic processes. Consecutively, gene expression may be modified, and/or structural modifications can occur in the offspring. A more detailed understanding of the early-life origins of diabetes mellitus and prediabetes is required for the development of preventive concepts and early treatment strategies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ensenauer, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hucklenbruch-Rother, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruell, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Doetsch, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-263996
DOI:	10.1007/s11428-016-0126-1
Journal or Publication Title:	Diabetologe
Volume:	12
Number:	6
Page Range:	S. 437 - 449
Date:	2016
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1860-9724
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INSULIN SENSITIVITY; GLUCOSE-TOLERANCE; MATERNAL OBESITY; RENAL-FUNCTION; BIRTH-WEIGHT; EXPOSURE; ADOLESCENTS; PREGNANCY; CHILDREN; FETAL Multiple languages Endocrinology & Metabolism Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26399