Koehler, Christoph (2016). Granulovacuolar degeneration: a neurodegenerative change that accompanies tau pathology. Acta Neuropathol., 132 (3). S. 339 - 360. NEW YORK: SPRINGER. ISSN 1432-0533

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Abstract

Granule-containing vacuoles in the cytoplasm of hippocampal neurons are a neuropathological feature of Alzheimer's disease. Granulovacuolar degeneration (GVD) is not disease-specific and can be observed in other neurodegenerative disorders and even in the brains of non-demented elderly people. However, several studies have reported much higher numbers of neurons undergoing GVD in the hippocampus of Alzheimer's disease cases. Recently, a neuropathological staging system for GVD has facilitated neuropathological assessment. Data obtained by electron microscopy and immunolabeling suggest that GVD inclusions are a special form of autophagic vacuole. GVD frequently occurs together with pathological changes of the microtubule-associated protein tau, but to date, the relationship between the two lesions remains elusive. Originally identified in hematoxylin- and silver-stained sections, immunolabeling has shown that the granules are composed of a variety of proteins, including those related to tau pathology, autophagy, diverse signal transduction pathways, cell stress and apoptosis. Several of these proteins serve as markers of GVD. Most researchers and authors have interpreted the sequestration of proteins into GVD inclusions as either a cellular defense mechanism or one that leads to the impairment of important cellular functions. This review provides a detailed overview of the various aspects of GVD and focuses on the relationship between tau pathology and GVD.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Koehler, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-264884
DOI: 10.1007/s00401-016-1562-0
Journal or Publication Title: Acta Neuropathol.
Volume: 132
Number: 3
Page Range: S. 339 - 360
Date: 2016
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1432-0533
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
UNFOLDED PROTEIN RESPONSE; AMYOTROPHIC-LATERAL-SCLEROSIS; PROGRESSIVE SUPRANUCLEAR PALSY; PLAQUE DYSTROPHIC DENDRITES; GLYCOGEN-SYNTHASE KINASE-3; PROLYL ISOMERASE PIN1; ALZHEIMERS-DISEASE; NEUROFIBRILLARY TANGLES; PHOSPHORYLATED-TAU; FRONTOTEMPORAL DEMENTIAMultiple languages
Clinical Neurology; Neurosciences; PathologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/26488

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