Universität zu Köln

Kukolja, Juraj ORCID: 0000-0003-1569-3287, Goereci, D. Yasemin, Onur, Oezguer A., Riedl, Valentin ORCID: 0000-0002-2861-8449 and Fink, Gereon R. ORCID: 0000-0002-8230-1856 (2016). Resting-state fMRI evidence for early episodic memory consolidation: effects of age. Neurobiol. Aging, 45. S. 197 - 212. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1558-1497

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Abstract

Aging-related episodic memory decline is often attributed to insufficient encoding of new information, although the underlying neural processes remain elusive. We here tested the hypothesis that impaired memory consolidation contributes to aging-related memory decline. To this end, we used resting state functional magnetic resonance imaging in healthy young and older adults and investigated neural network connectivity underlying episodic memory consolidation and the effects of aging thereon. During postencoding rest, connectivity increased in subregions of temporobasal and temporo-occipital networks but decreased in a precuneal network. These connectivity changes predicted subsequent memory performance thereby constituting functional correlates of early memory consolidation. Furthermore, these consolidation-related regional connectivity changes partially overlapped with encoding-related neural activity changes, suggesting a close relationship between encoding-and consolidation-related activity. Older when compared to young participants failed to increase connectivity in the right lingual gyrus as part of an extended default mode network during consolidation, thereby providing a functional correlate for spatial contextual memory deficits. In conclusion, results are consistent with previous reports of persistent activity in regions mediating memory encoding as a core mechanism underlying episodic memory consolidation. Our data extend previous findings suggesting that aging-related memory decline results from a reduction of consolidation processes. (C) 2016 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kukolja, Juraj UNSPECIFIED orcid.org/0000-0003-1569-3287 UNSPECIFIED Goereci, D. Yasemin UNSPECIFIED UNSPECIFIED UNSPECIFIED Onur, Oezguer A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedl, Valentin UNSPECIFIED orcid.org/0000-0002-2861-8449 UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-265929
DOI:	10.1016/j.neurobiolaging.2016.06.004
Journal or Publication Title:	Neurobiol. Aging
Volume:	45
Page Range:	S. 197 - 212
Date:	2016
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1558-1497
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LONGITUDINAL DATA-ANALYSIS; DEFAULT-MODE NETWORK; FUNCTIONAL CONNECTIVITY; BRAIN ACTIVITY; NEURAL MECHANISMS; TIME-SERIES; REACTIVATION; HIPPOCAMPAL; RETRIEVAL; PRECUNEUS Multiple languages Geriatrics & Gerontology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26592