Universität zu Köln

Krewer, Carmen ORCID: 0000-0002-4153-0791, Schneider, Manfred, Schneider, Harald Joern, Kreitschmann-Andermahr, Ilonka, Buchfelder, Michael, Faust, Michael, Berg, Christian, Wallaschofski, Henri, Renner, Caroline, Uhl, Eberhard, Koenig, Eberhard, Jordan, Martina, Stalla, Guenter Karl and Kopczak, Anna (2016). Neuroendocrine Disturbances One to Five or More Years after Traumatic Brain Injury and Aneurysmal Subarachnoid Hemorrhage: Data from the German Database on Hypopituitarism. J. Neurotrauma, 33 (16). S. 1544 - 1554. NEW ROCHELLE: MARY ANN LIEBERT, INC. ISSN 1557-9042

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Abstract

Neuroendocrine disturbances are common after traumatic brain injury (TBI) and aneurysmal subarachnoid hemorrhage (SAH), but only a few data exist on long-term anterior pituitary deficiencies after brain injury. We present data from the Structured Data Assessment of Hypopituitarism after TBI and SAH, a multi-center study including 1242 patients. We studied a subgroup of 351 patients, who had sustained a TBI (245) or SAH (106) at least 1 year before endocrine assessment (range 1-55 years) in a separate analysis. The highest prevalence of neuroendocrine disorders was observed 1-2 years post-injury, and it decreased over time only to show another maximum in the long-term phase in patients with brain injury occurring >= 5 years prior to assessment. Gonadotropic and somatotropic insufficiencies were most common. In the subgroup from 1 to 2 years after brain injury (n = 126), gonadotropic insufficiency was the most common hormonal disturbance (19%, 12/63 men) followed by somatotropic insufficiency (11.5%, 7/61), corticotropic insufficiency (9.2%, 11/119), and thyrotropic insufficiency (3.3%, 4/122). In patients observed >= 5 years after brain injury, the prevalence of somatotropic insufficiency increased over time to 24.1%, whereas corticotropic and thyrotrophic insufficiency became less frequent (2.5% and 0%, respectively). The prevalence differed regarding the diagnostic criteria (laboratory values vs. physician's diagnosis vs. stimulation tests). Our data showed that neuroendocrine disturbances are frequent even years after TBI or SAH, in a cohort of patients who are still on medical treatment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Krewer, Carmen UNSPECIFIED orcid.org/0000-0002-4153-0791 UNSPECIFIED Schneider, Manfred UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Harald Joern UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreitschmann-Andermahr, Ilonka UNSPECIFIED UNSPECIFIED UNSPECIFIED Buchfelder, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Faust, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Wallaschofski, Henri UNSPECIFIED UNSPECIFIED UNSPECIFIED Renner, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Uhl, Eberhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenig, Eberhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Jordan, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Stalla, Guenter Karl UNSPECIFIED UNSPECIFIED UNSPECIFIED Kopczak, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-266549
DOI:	10.1089/neu.2015.4109
Journal or Publication Title:	J. Neurotrauma
Volume:	33
Number:	16
Page Range:	S. 1544 - 1554
Date:	2016
Publisher:	MARY ANN LIEBERT, INC
Place of Publication:	NEW ROCHELLE
ISSN:	1557-9042
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTERIOR-PITUITARY FUNCTION; GROWTH-HORMONE DEFICIENCY; LONG-TERM; PRACTICAL SCALE; FOLLOW-UP; PREVALENCE; DYSFUNCTION; SURVIVORS; STRESS; ADULTS Multiple languages Critical Care Medicine; Clinical Neurology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26654