Universität zu Köln

Nakad, Rania and Schumacher, Bjoern (2016). DNA Damage Response and Immune Defense: Links and Mechanisms. Front. Genet., 7. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-8021

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Abstract

DNA damage plays a causal role in numerous human pathologies including cancer, premature aging, and chronic inflammatory conditions. In response to genotoxic insults, the DNA damage response (DDR) orchestrates DNA damage checkpoint activation and facilitates the removal of DNA lesions. The DDR can also arouse the immune system by for example inducing the expression of antimicrobial peptides as well as ligands for receptors found on immune cells. The activation of immune signaling is triggered by different components of the DDR including DNA damage sensors, transducer kinases, and effectors. In this review, we describe recent advances on the understanding of the role of DDR in activating immune signaling. We highlight evidence gained into (i) which molecular and cellular pathways of DDR activate immune signaling, (ii) how DNA damage drives chronic inflammation, and (iii) how chronic inflammation causes DNA damage and pathology in humans.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Nakad, Rania UNSPECIFIED UNSPECIFIED UNSPECIFIED Schumacher, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-266684
DOI:	10.3389/fgene.2016.00147
Journal or Publication Title:	Front. Genet.
Volume:	7
Date:	2016
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-8021
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STRAND BREAK REPAIR; TOLL-LIKE RECEPTORS; OXIDATIVE STRESS; CYTOSOLIC DNA; CHRONIC INFLAMMATION; CHECKPOINT ACTIVATION; ENDOTHELIAL-CELLS; EXCISION-REPAIR; I INTERFERONS; NITRIC-OXIDE Multiple languages Genetics & Heredity Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26668