Universität zu Köln

Biskup, C. S., Helmbold, K., Baurmann, D., Klasen, M., Gaber, T. J., Bubenzer-Busch, S., Koenigschulte, W., Fink, G. R. and Zepf, F. D. (2016). Resting state default mode network connectivity in children and adolescents with ADHD after acute tryptophan depletion. Acta Psychiatr. Scand., 134 (2). S. 161 - 172. HOBOKEN: WILEY. ISSN 1600-0447

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Abstract

Objective: Alterations of the default mode network (DMN) have been described in patients with neuropsychiatric disorders, including attention deficit hyperactivity disorder (ADHD), and the neurotransmitter serotonin (5-HT) is known to modulate DMN activity. This study aimed to explore the role of 5-HT on the DMN and its functional connectivity (FC) in young patients with ADHD. Methods: Young male patients with ADHD (n = 12) and healthy controls (n = 10) (both aged 12-17 years) were subjected to acute tryptophan depletion (ATD) and subsequently diminished brain 5-HT synthesis. Three hours after challenge intake (ATD or a balanced control condition, BAL), resting state fMRI scans were obtained. Results: In patients, ATD led to attenuated FC of the right superior premotor cortex (BA 6) with the DMN, comparable to the extent found in controls after BAL administration. ATD lowered FC of the left somatosensory cortex (BA 3) with the DMN, independently of the factor group, but with stronger effects in controls. Conclusions: Data reveal a serotonergic modulation of FC between BA 6 and 3, known to be relevant for motor planning and sensory perception, and the DMN, thereby possibly pointing toward ATD acting beneficially on neural planning of motor activity in patients with ADHD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Biskup, C. S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Helmbold, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baurmann, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klasen, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaber, T. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bubenzer-Busch, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenigschulte, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, G. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zepf, F. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-268620
DOI:	10.1111/acps.12573
Journal or Publication Title:	Acta Psychiatr. Scand.
Volume:	134
Number:	2
Page Range:	S. 161 - 172
Date:	2016
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-0447
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY DISORDER; FUNCTIONAL CONNECTIVITY; BRAIN-FUNCTION; ANTERIOR CINGULATE; PREFRONTAL CORTEX; YOUNG-PEOPLE; ADULT ADHD; SELF; SEROTONIN Multiple languages Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26862