Universität zu Köln

Hoyer-Kuhn, Heike, Hoebing, Laura, Cassens, Julia, Schoenau, Eckhard and Semler, Oliver (2016). Children with severe Osteogenesis imperfecta and short stature present on average with normal IGF-I and IGFBP-3 levels. J. Pediatr. Endocrinol. Metab., 29 (7). S. 813 - 819. BERLIN: WALTER DE GRUYTER GMBH. ISSN 2191-0251

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Abstract

Background: Osteogenesis imperfecta (OI) is characterized by bone fragility and short stature. Data about IGF-I/IGFBP-3 levels are rare in OI. Therefore IGF-I/IGFBP-3 levels in children with different types of OI were investigated. Methods: IGF-I and IGFBP-3 levels of 60 children (male n=38) were assessed in a retrospective cross-sectional setting. Results: Height/weight was significant different [height z-score type 3 versus type 4: p=0.0011 and weight (p <= 0.0001)] between OI type 3 and 4. Mean IGF-I levels were in the lower normal range (mean +/- SD level 137.4 +/- 109.1 mu g/L). Mean IGFBP-3 measurements were in the normal range (mean +/- SD 3.105 +/- 1.175 mg/L). No significant differences between OI type 3 and 4 children have been observed (IGF-I: p=0.0906; IGFBP-3: p=0.2042). Conclusions: Patients with different severities of OI have IGF-I and IGFBP-3 levels in the lower normal range. The type of OI does not significantly influence these growth factors.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hoyer-Kuhn, Heike UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoebing, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Cassens, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenau, Eckhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Semler, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-270962
DOI:	10.1515/jpem-2015-0385
Journal or Publication Title:	J. Pediatr. Endocrinol. Metab.
Volume:	29
Number:	7
Page Range:	S. 813 - 819
Date:	2016
Publisher:	WALTER DE GRUYTER GMBH
Place of Publication:	BERLIN
ISSN:	2191-0251
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GROWTH-HORMONE TREATMENT; BONE; ADOLESCENTS; THERAPY; HEIGHT; AXIS Multiple languages Endocrinology & Metabolism; Pediatrics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27096