Universität zu Köln

Diehl, Anja, Volland, Ruth, Kirn, Verena, Thangarajah, Fabinshy, Eichler, Christian, Einzmann, Thomas, Wirtz, Marina, Ratiu, Dominik, Morgenstern, Bernd, Fridrich, Claudius, Mallmann, Peter and Puppe, Julian (2016). The number of removed lymph nodes by inguinofemoral lymphadenectomy: impact on recurrence rates in patients with vulva carcinoma. Arch. Gynecol. Obstet., 294 (1). S. 131 - 137. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-0711

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Abstract

Objective Inguinal lymph node (LN) metastasis is a crucial prognostic factor in vulva carcinoma. The aim of this study was to determine the prognostic value of the number of resected LNs in patients with vulvar carcinoma on recurrence rates. Methods This retrospective study includes patients with vulvar squamous cell carcinoma who underwent inguinofemoral lymphadenectomy (IFL) between 1998 and 2011. Dissected groins were stratified by the number of removed lymph nodes (<6 LNs versus >= 6 LNs) or inguinal LN metastasis (pN- versus pN+) and analyzed according to groin, local and distance recurrence rates. Results In total 45 patients were identified and 79 groins were eligible for this analysis. 11 patients underwent ipsilateral IFL and 34 bilateral IFL. The median age was 58 years (range 31-80). The median tumor size was 2 cm (range 0.1-7.9). A median of 8 (range 0-19) LNs were resected per groin. Overall in 11 groins LN metastases were found. Groin recurrences occurred in four patients, local recurrence in six patients and distant metastasis in one patient. We did not observe any significant improvement in groin recurrence rates, local recurrence rates and distant recurrence rates if more than six LNs were removed per groin. Notably, patients with LN metastasis did not show higher recurrence rates compared to unaffected LNs. Conclusion In this cohort we demonstrated that resection of more than six LNs per groin does not improve the recurrence rates in patients with carcinoma of the vulva. Further prospective studies with more individuals are needed to evaluate the role of resected LNs in vulvar carcinoma.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Diehl, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Volland, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirn, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Thangarajah, Fabinshy UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichler, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Einzmann, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Wirtz, Marina UNSPECIFIED UNSPECIFIED UNSPECIFIED Ratiu, Dominik UNSPECIFIED UNSPECIFIED UNSPECIFIED Morgenstern, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Fridrich, Claudius UNSPECIFIED UNSPECIFIED UNSPECIFIED Mallmann, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Puppe, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-271037
DOI:	10.1007/s00404-015-3932-6
Journal or Publication Title:	Arch. Gynecol. Obstet.
Volume:	294
Number:	1
Page Range:	S. 131 - 137
Date:	2016
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-0711
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SQUAMOUS-CELL CARCINOMA; GROIN RECURRENCE; PROGNOSTIC-FACTORS; CANCER; MANAGEMENT; DISSECTION; COUNT Multiple languages Obstetrics & Gynecology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27103