Fernando, Ruani N., Chaudhari, Umesh ORCID: 0000-0002-7743-4371, Escher, Sylvia E., Hengstler, Jan G., Hescheler, Juergen, Jennings, Paul ORCID: 0000-0002-6860-2898, Keun, Hector C., Kleinjans, Jos C. S., Kolde, Raivo ORCID: 0000-0003-2886-6298, Kollipara, Laxmikanth, Kopp-Schneider, Annette, Limonciel, Alice ORCID: 0000-0001-6588-5944, Nemade, Harshal, Nguemo, Filomain, Peterson, Hedi ORCID: 0000-0001-9951-5116, Prieto, Pilar, Rodrigues, Robim M., Sachinidis, Agapios, Schaefer, Christoph, Sickmann, Albert ORCID: 0000-0002-2388-5265, Spitkovsky, Dimitry, Stoeber, Regina, van Breda, Simone G. J., van de Water, Bob, Vivier, Manon, Zahedi, Rene P., Vinken, Mathieu ORCID: 0000-0001-5115-8893 and Rogiers, Vera ORCID: 0000-0003-0635-7740 (2016). Watching the Detectives report of the general assembly of the EU project DETECTIVE Brussels, 24-25 November 2015. Arch. Toxicol., 90 (6). S. 1529 - 1540. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-0738

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Abstract

SEURAT-1 is a joint research initiative between the European Commission and Cosmetics Europe aiming to develop in vitro- and in silico-based methods to replace the in vivo repeated dose systemic toxicity test used for the assessment of human safety. As one of the building blocks of SEURAT-1, the DETECTIVE project focused on a key element on which in vitro toxicity testing relies: the development of robust and reliable, sensitive and specific in vitro biomarkers and surrogate endpoints that can be used for safety assessments of chronically acting toxicants, relevant for humans. The work conducted by the DETECTIVE consortium partners has established a screening pipeline of functional and -omics technologies, including high-content and high-throughput screening platforms, to develop and investigate human biomarkers for repeated dose toxicity in cellular in vitro models. Identification and statistical selection of highly predictive biomarkers in a pathway- and evidence-based approach constitute a major step in an integrated approach towards the replacement of animal testing in human safety assessment. To discuss the final outcomes and achievements of the consortium, a meeting was organized in Brussels. This meeting brought together data-producing and supporting consortium partners. The presentations focused on the current state of ongoing and concluding projects and the strategies employed to identify new relevant biomarkers of toxicity. The outcomes and deliverables, including the dissemination of results in data-rich -omics databases, were discussed as were the future perspectives of the work completed under the DETECTIVE project. Although some projects were still in progress and required continued data analysis, this report summarizes the presentations, discussions and the outcomes of the project.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Fernando, Ruani N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chaudhari, UmeshUNSPECIFIEDorcid.org/0000-0002-7743-4371UNSPECIFIED
Escher, Sylvia E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hengstler, Jan G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hescheler, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jennings, PaulUNSPECIFIEDorcid.org/0000-0002-6860-2898UNSPECIFIED
Keun, Hector C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kleinjans, Jos C. S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kolde, RaivoUNSPECIFIEDorcid.org/0000-0003-2886-6298UNSPECIFIED
Kollipara, LaxmikanthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kopp-Schneider, AnnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Limonciel, AliceUNSPECIFIEDorcid.org/0000-0001-6588-5944UNSPECIFIED
Nemade, HarshalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nguemo, FilomainUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peterson, HediUNSPECIFIEDorcid.org/0000-0001-9951-5116UNSPECIFIED
Prieto, PilarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodrigues, Robim M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sachinidis, AgapiosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaefer, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sickmann, AlbertUNSPECIFIEDorcid.org/0000-0002-2388-5265UNSPECIFIED
Spitkovsky, DimitryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoeber, ReginaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Breda, Simone G. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van de Water, BobUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vivier, ManonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zahedi, Rene P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vinken, MathieuUNSPECIFIEDorcid.org/0000-0001-5115-8893UNSPECIFIED
Rogiers, VeraUNSPECIFIEDorcid.org/0000-0003-0635-7740UNSPECIFIED
URN: urn:nbn:de:hbz:38-273972
DOI: 10.1007/s00204-016-1719-6
Journal or Publication Title: Arch. Toxicol.
Volume: 90
Number: 6
Page Range: S. 1529 - 1540
Date: 2016
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1432-0738
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NEPHROTOXICITY; OCHRATOXIN; PATHWAYS; DRUGSMultiple languages
ToxicologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/27397

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