Hohberg, Melanie, Eschner, Wolfgang, Schmidt, Matthias, Dietlein, Markus, Kobe, Carsten, Fischer, Thomas, Drzezga, Alexander and Wild, Markus (2016). Lacrimal Glands May Represent Organs at Risk for Radionuclide Therapy of Prostate Cancer with [Lu-177]DKFZ-PSMA-617. Mol. Imaging. Biol., 18 (3). S. 437 - 446. NEW YORK: SPRINGER. ISSN 1860-2002

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Abstract

Calculating the absorbed dose is important for the determination of risk and therapeutic benefit of internal radiation therapy. The aim of this study was to perform image-based absorbed dose calculation for critical organs during the first cycle of [Lu-177]DKFZ-PSMA-617 therapy in a small cohort of patients with metastatic prostate cancer. Nine patients with a history of prostate cancer documented by histopathology and radiologic evidence of metastatic diseases underwent radioligand therapy with [Lu-177]DKFZ-PSMA-617. Conjugated planar whole-body scintigraphies acquired at 0.5, 24, 48, 72, and 168 h post-injection were analyzed by regions of interest, and time-activity curves were generated for various organs. Cumulated activities and residence times were calculated by bi-exponential fit of the time-activity curves. Mean absorbed doses were finally estimated using OLINDA/EXM1.1 (TM). Additionally, the uncertainty when omitting the last measurement (168 h p.i.) was studied. The following mean absorbed doses were calculated: 2.82 mGy/MBq for the lacrimal glands, 0.72 mGy/MBq for the salivary glands, 0.53 mGy/MBq for the kidneys, and 0.42 mGy/MBq for the nasal mucous membrane. Omitting the last measurement resulted in a mean deviation of 10 to 25 % for absorbed dose values as compared to the ones received by analyzing all measurements. Absorbed organ doses of [Lu-177]DKFZ-PSMA-617 therapy are not likely to be critical for kidneys, salivary glands, and the nasal mucous membrane. The lacrimal glands may represent the dose-limiting organs. Whole-body scintigraphy appears sufficient for dose estimation, but late measurements are mandatory, if accurate dose calculation is required.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hohberg, MelanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eschner, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dietlein, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kobe, CarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drzezga, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wild, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-274110
DOI: 10.1007/s11307-016-0942-0
Journal or Publication Title: Mol. Imaging. Biol.
Volume: 18
Number: 3
Page Range: S. 437 - 446
Date: 2016
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1860-2002
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MEMBRANE ANTIGEN; PSMA INHIBITOR; DOSIMETRY; EXPRESSION; LIGAND; PETMultiple languages
Radiology, Nuclear Medicine & Medical ImagingMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/27411

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