Bagci, Soyhan ORCID: 0000-0003-1005-665X, Brosens, Erwin ORCID: 0000-0001-8235-4010, Tibboel, Dick, De Klein, Annelies, Ijsselstijn, Hanneke, Wijers, Charlotte H. W., Roeleveld, Nel ORCID: 0000-0002-3390-4466, de Blaauw, Ivo, Broens, Paul M., van Rooij, Iris A. L. M., Hoelscher, Alice, Boemers, Thomas M., Pauly, Marcus, Muensterer, Oliver J., Schmiedeke, Eberhard, Schaefer, Mattias, Ure, Benno E., Lacher, Martin, Choinitzki, Vera, Schumacher, Johannes ORCID: 0000-0001-9217-6457, Zwink, Nadine, Jenetzky, Ekkehart ORCID: 0000-0001-5415-8784, Katzer, David, Arand, Joerg, Bartmann, Peter and Reutter, Heiko M. (2016). More than fetal urine: enteral uptake of amniotic fluid as a major predictor for fetal growth during late gestation. Eur. J. Pediatr., 175 (6). S. 825 - 832. NEW YORK: SPRINGER. ISSN 1432-1076

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Abstract

The purpose of our study was to investigate the importance of amniotic fluid (AF) for fetal growth during late gestation using esophageal atresia (EA) patients as a model. In this retrospective cohort study, we compared the z-scores adapted for birth weights (BW z-scores) for each of 517 European newborns with congenital pre-gastric intestinal atresia, i.e., EA, to a European reference population. To account for the influence of the intestinal atresia on fetal growth per se, we compared adapted birth weights for each of 504 European newborns with post colonic intestinal atresia (anorectal malformation (ARM) with atresia of the anus) to the same European reference population. Analysis of the complete cohort showed (i) a significantly higher rate of small for gestational age newborns among EA compared to ARM newborns (p < 0.001) and (ii) significantly lower BW z-scores among EA compared to ARM newborns (p < 0.001). BW z-scores of EA newborns were significantly lower in term compared to preterm newborns with an inverse correlation with gestational age (GA) (Spearman correlation coefficient, r = -0.185, p < 0.001). Conclusions: Enteral uptake of AF seems to play a pivotal role in fetal growth during late gestation.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bagci, SoyhanUNSPECIFIEDorcid.org/0000-0003-1005-665XUNSPECIFIED
Brosens, ErwinUNSPECIFIEDorcid.org/0000-0001-8235-4010UNSPECIFIED
Tibboel, DickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Klein, AnneliesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ijsselstijn, HannekeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wijers, Charlotte H. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roeleveld, NelUNSPECIFIEDorcid.org/0000-0002-3390-4466UNSPECIFIED
de Blaauw, IvoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Broens, Paul M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Rooij, Iris A. L. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoelscher, AliceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boemers, Thomas M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pauly, MarcusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muensterer, Oliver J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmiedeke, EberhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaefer, MattiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ure, Benno E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lacher, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Choinitzki, VeraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schumacher, JohannesUNSPECIFIEDorcid.org/0000-0001-9217-6457UNSPECIFIED
Zwink, NadineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jenetzky, EkkehartUNSPECIFIEDorcid.org/0000-0001-5415-8784UNSPECIFIED
Katzer, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arand, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bartmann, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reutter, Heiko M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-274458
DOI: 10.1007/s00431-016-2713-y
Journal or Publication Title: Eur. J. Pediatr.
Volume: 175
Number: 6
Page Range: S. 825 - 832
Date: 2016
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1432-1076
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BIOCHEMICAL-COMPOSITION; ESOPHAGEAL LIGATION; MATERNAL SERUM; PREGNANCY; PROTEIN; CLASSIFICATION; RETARDATION; NUTRITION; TURNOVER; VOLUMEMultiple languages
PediatricsMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/27445

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