Universität zu Köln

Gloeckner, Gernot, Lawal, Hajara M., Felder, Marius, Singh, Reema ORCID: 0000-0001-7049-5473, Singer, Gail, Weijer, Cornelis J. and Schaap, Pauline ORCID: 0000-0003-4500-2555 (2016). The multicellularity genes of dictyostelid social amoebas. Nat. Commun., 7. BERLIN: NATURE RESEARCH. ISSN 2041-1723

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Abstract

The evolution of multicellularity enabled specialization of cells, but required novel signalling mechanisms for regulating cell differentiation. Early multicellular organisms are mostly extinct and the origins of these mechanisms are unknown. Here using comparative genome and transcriptome analysis across eight uni- and multicellular amoebozoan genomes, we find that 80% of proteins essential for the development of multicellular Dictyostelia are already present in their unicellular relatives. This set is enriched in cytosolic and nuclear proteins, and protein kinases. The remaining 20%, unique to Dictyostelia, mostly consists of extracellularly exposed and secreted proteins, with roles in sensing and recognition, while several genes for synthesis of signals that induce cell-type specialization were acquired by lateral gene transfer. Across Dictyostelia, changes in gene expression correspond more strongly with phenotypic innovation than changes in protein functional domains. We conclude that the transition to multicellularity required novel signals and sensors rather than novel signal processing mechanisms.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gloeckner, Gernot UNSPECIFIED UNSPECIFIED UNSPECIFIED Lawal, Hajara M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Felder, Marius UNSPECIFIED UNSPECIFIED UNSPECIFIED Singh, Reema UNSPECIFIED orcid.org/0000-0001-7049-5473 UNSPECIFIED Singer, Gail UNSPECIFIED UNSPECIFIED UNSPECIFIED Weijer, Cornelis J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaap, Pauline UNSPECIFIED orcid.org/0000-0003-4500-2555 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-274731
DOI:	10.1038/ncomms12085
Journal or Publication Title:	Nat. Commun.
Volume:	7
Date:	2016
Publisher:	NATURE RESEARCH
Place of Publication:	BERLIN
ISSN:	2041-1723
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL-DIFFERENTIATION; EXPERIMENTAL EVOLUTION; GENOME REVEALS; RESISTANCE; DISCOIDEUM; PROTEIN; GSK3; SPECIALIZATION; IDENTIFICATION; DISCADENINE Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27473