Universität zu Köln

Arber, Daniel A., Orazi, Attilio, Hasserjian, Robert, Thiele, Jurgen, Borowitz, Michael J., Le Beau, Michelle M., Bloomfield, Clara D., Cazzola, Mario and Vardiman, James W. (2016). The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood, 127 (20). S. 2391 - 2406. WASHINGTON: AMER SOC HEMATOLOGY. ISSN 1528-0020

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Abstract

The World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues was last updated in 2008. Since then, there have been numerous advances in the identification of unique biomarkers associated with some myeloid neoplasms and acute leukemias, largely derived from gene expression analysis and next-generation sequencing that can significantly improve the diagnostic criteria as well as the prognostic relevance of entities currently included in the WHO classification and that also suggest new entities that should be added. Therefore, there is a clear need for a revision to the current classification. The revisions to the categories of myeloid neoplasms and acute leukemia will be published in a monograph in 2016 and reflect a consensus of opinion of hematopathologists, hematologists, oncologists, and geneticists. The 2016 edition represents a revision of the prior classification rather than an entirely new classification and attempts to incorporate new clinical, prognostic, morphologic, immunophenotypic, and genetic data that have emerged since the last edition. The major changes in the classification and their rationale are presented here.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Arber, Daniel A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Orazi, Attilio UNSPECIFIED UNSPECIFIED UNSPECIFIED Hasserjian, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Thiele, Jurgen UNSPECIFIED UNSPECIFIED UNSPECIFIED Borowitz, Michael J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Le Beau, Michelle M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloomfield, Clara D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cazzola, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Vardiman, James W. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-275614
DOI:	10.1182/blood-2016-03-643544
Journal or Publication Title:	Blood
Volume:	127
Number:	20
Page Range:	S. 2391 - 2406
Date:	2016
Publisher:	AMER SOC HEMATOLOGY
Place of Publication:	WASHINGTON
ISSN:	1528-0020
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACUTE LYMPHOBLASTIC-LEUKEMIA; SINGLE CEBPA MUTATIONS; CHRONIC MYELOMONOCYTIC LEUKEMIA; INTERMEDIATE-RISK CYTOGENETICS; MYELODYSPLASTIC SYNDROMES MDS; ACUTE ERYTHROID LEUKEMIA; PHENOTYPE ACUTE-LEUKEMIA; ESSENTIAL THROMBOCYTHEMIA; MULTILINEAGE DYSPLASIA; CLONAL HEMATOPOIESIS Multiple languages Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27561