Universität zu Köln

Holle, J. F., Jessen, F. and Kuhn, J. (2016). Clinical Phenomenology of Autoimmune Encephalitis. Forschritte Neurol. Psychiatr., 84 (5). S. 271 - 281. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3522

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Abstract

Antibody-associated disorders of the central nervous system constitute a heterogeneous group of disorders that can be roughly divided into two categories: Classic paraneoplastic syndromes associated with so-called well-characterized antibodies (paraneoplastic neurological disorders, PND) and autoimmune disorders with antibodies to membrane-bound or synaptic antigens (autoimmune encephalitis, AE). The discovery of autoimmune encephalitis has led to a paradigm shift in diagnosis and therapy as well as a reclassification of some neuropsychiatric syndromes that were previously classified as idiopathic or simply covered with descriptive terms. In this review article, especially clinical aspects of autoimmune encephalitis will be discussed, as there has been a rapid increase in knowledge in this regard within the past decade; increasingly overlap syndromes and associations with other disease entities have been detected. In addition togeneral aspects, characteristics of anti-NMDAR-, anti-LGI1-, anti-GABA(A) and GABA(B)R, anti-AMPAR-, anti-CASPR2-, anti-mGluR, anti-GlycinR-, anti-GAD, anti- DPPX- and anti-D2R encephalitis and the anti-IgLON5 encephalopathy will be presented.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Holle, J. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-276320
DOI:	10.1055/s-0042-104194
Journal or Publication Title:	Forschritte Neurol. Psychiatr.
Volume:	84
Number:	5
Page Range:	S. 271 - 281
Date:	2016
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3522
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NMDA RECEPTOR ENCEPHALITIS; PARANEOPLASTIC LIMBIC ENCEPHALITIS; STIFF-MAN SYNDROME; SIMPLEX-VIRUS ENCEPHALITIS; RAPID-EYE-MOVEMENT; PROGRESSIVE ENCEPHALOMYELITIS; STATUS EPILEPTICUS; GABA(A) RECEPTOR; OPHELIA SYNDROME; CASE SERIES Multiple languages Clinical Neurology; Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27632