Tian, Feng, Han, Yong, Song, Jian, Lei, Jie, Yan, Xiaolong ORCID: 0000-0003-2419-9707, Xie, Nianlin, Wang, Jian, Zhao, Jinbo, Liang, Xiaohua, Zhong, Daixing, Zhou, Yongan, Wang, Xiaoping and Li, Xiaofei (2016). Pulmonary resident neutrophils regulate the production of GM-CSF and alveolar macrophages. FEBS J., 283 (8). S. 1465 - 1475. HOBOKEN: WILEY. ISSN 1742-4658

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Abstract

Alveolar macrophages exist in the lung airspaces, and their differentiation and function are considerably regulated by the microenvironment. In this study, we examine the important role of resident neutrophil/IL-23/granulocyte/macrophage colony-stimulating factor (GM-CSF) axis in the development and preferential phenotype of alveolar macrophages under physiological conditions. Using CD18-deficient (CD18(-/-)) mice, we show a correlation between increased granulopoiesis and enhanced alveolar macrophage development in an IL-23- and GM-CSF-dependent manner. The apoptotic neutrophils could inhibit the secretion of IL-23 from alveolar macrophages, which is important for the production of GM-CSF, and depletion of neutrophils disrupted the regulation of IL-23 and GM-CSF. This study reveals a mechanism for the regulation of the local alveolar macrophage population and function by neutrophil apoptosis in the circulatory system.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Tian, FengUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Han, YongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Song, JianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lei, JieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yan, XiaolongUNSPECIFIEDorcid.org/0000-0003-2419-9707UNSPECIFIED
Xie, NianlinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, JianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhao, JinboUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liang, XiaohuaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhong, DaixingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhou, YonganUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, XiaopingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, XiaofeiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-279720
DOI: 10.1111/febs.13684
Journal or Publication Title: FEBS J.
Volume: 283
Number: 8
Page Range: S. 1465 - 1475
Date: 2016
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1742-4658
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
COLONY-STIMULATING FACTOR; INNATE LYMPHOID-CELLS; FETAL MONOCYTES; GRANULOPOIESIS; PHAGOCYTOSIS; HOMEOSTASIS; FIBROSIS; IL-23; GAMMA; LUNGMultiple languages
Biochemistry & Molecular BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/27972

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