Universität zu Köln

Hoffmann, Christian, Schommers, Philipp ORCID: 0000-0003-3375-6800, Wolf, Eva, Mueller, Markus, Schultze, Alexander, Krznaric, Ivanka, Stoehr, Albrecht, Wolf, Timo, Faektenheuer, Gerd, Stier, Bastian, Wyen, Christoph and Hentrich, Marcus (2016). CD4(+) and CD8(+) T-cell kinetics in aviremic HIV-infected patients developing Hodgkin or non-Hodgkin lymphoma. Aids, 30 (5). S. 753 - 761. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1473-5571

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Abstract

Objective: The risk of non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) is increased in HIV-infected individuals. We studied the kinetics of lymphocyte subsets in patients who subsequently developed HL or NHL while on virologically suppressive antiretroviral therapy (ART). Design: Using a nested case-control design, cases of HIV+ HL or NHL were selected from two prospective clinical studies. Aviremia was defined as less than 200 HIV-RNA copies/ml for at least 6 months prior to lymphoma diagnosis. Each case was matched to three aviremic HIV+ controls without lymphoma. Results: In the 81 cases (50 HL and 31 NHL), prediagnostic CD4(+) T cells and CD8(+) T cells displayed discordant kinetics compared with controls. Within the last and within the next-to-last year preceding HL diagnosis, mean CD4(+) T cells decreased by -168 and by -2 cells/mu l, compared with an increase of +44 and +73 cells/mu l in the controls, respectively. Mean CD8(+) T cells decreased by -352 and -115 cells/mu l, compared with nonsignificant changes of -29 and +/- 0 cells/mu l in the controls, respectively. T-cell kinetics demonstrated a marked inter-individual variability. Kinetics of CD4(+) and CD8(+) T cells were also discordant between NHL cases and controls. Conclusion: This study on a large number of aviremic patients developing HL and NHL who were carefully matched with controls, gives insights to prediagnostic kinetics of immune parameters. The discordant kinetics of both CD4(+) and CD8(+) T cells are already seen 1-2 years prior to lymphoma diagnosis, are more pronounced during the last year and in patients developing HL but are also seen in NHL.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hoffmann, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Schommers, Philipp UNSPECIFIED orcid.org/0000-0003-3375-6800 UNSPECIFIED Wolf, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Schultze, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Krznaric, Ivanka UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoehr, Albrecht UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolf, Timo UNSPECIFIED UNSPECIFIED UNSPECIFIED Faektenheuer, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Stier, Bastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Wyen, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Hentrich, Marcus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-281498
DOI:	10.1097/QAD.0000000000000980
Journal or Publication Title:	Aids
Volume:	30
Number:	5
Page Range:	S. 753 - 761
Date:	2016
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1473-5571
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PERIPHERAL-BLOOD; UNITED-STATES; RISK; COHORT; INDIVIDUALS; DISEASE; CANCER; IMMUNODEFICIENCY; MICROENVIRONMENT; MULTICENTER Multiple languages Immunology; Infectious Diseases; Virology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28149