Reale, Carla ORCID: 0000-0001-7682-4784, Iervolino, Anna, Scudiero, Ivan, Ferravante, Angela, D'Andrea, Luca Egildo, Mazzone, Pellegrino, Zotti, Tiziana, Leonardi, Antonio, Roberto, Luca, Zannini, Mariastella, de Cristofaro, Tiziana, Shanmugakonar, Muralitharan, Capasso, Giovambattista ORCID: 0000-0003-3469-8614, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Vito, Pasquale and Stilo, Romania (2016). NF-B Essential Modulator (NEMO) Is Critical for Thyroid Function. J. Biol. Chem., 291 (11). S. 5765 - 5774. BETHESDA: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC. ISSN 1083-351X

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Abstract

The I-B kinase (IKK) subunit NEMO/IKK (NEMO) is an adapter molecule that is critical for canonical activation of NF-B, a pleiotropic transcription factor controlling immunity, differentiation, cell growth, tumorigenesis, and apoptosis. To explore the functional role of canonical NF-B signaling in thyroid gland differentiation and function, we have generated a murine strain bearing a genetic deletion of the NEMO locus in thyroid. Here we show that thyrocyte-specific NEMO knock-out mice gradually develop hypothyroidism after birth, which leads to reduced body weight and shortened life span. Histological and molecular analysis indicate that absence of NEMO in thyrocytes results in a dramatic loss of the thyroid gland cellularity, associated with down-regulation of thyroid differentiation markers and ongoing apoptosis. Thus, NEMO-dependent signaling is essential for normal thyroid physiology.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Reale, CarlaUNSPECIFIEDorcid.org/0000-0001-7682-4784UNSPECIFIED
Iervolino, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scudiero, IvanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferravante, AngelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
D'Andrea, Luca EgildoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mazzone, PellegrinoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zotti, TizianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leonardi, AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roberto, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zannini, MariastellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Cristofaro, TizianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shanmugakonar, MuralitharanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Capasso, GiovambattistaUNSPECIFIEDorcid.org/0000-0003-3469-8614UNSPECIFIED
Pasparakis, ManolisUNSPECIFIEDorcid.org/0000-0002-9870-0966UNSPECIFIED
Vito, PasqualeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stilo, RomaniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-281567
DOI: 10.1074/jbc.M115.711697
Journal or Publication Title: J. Biol. Chem.
Volume: 291
Number: 11
Page Range: S. 5765 - 5774
Date: 2016
Publisher: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Place of Publication: BETHESDA
ISSN: 1083-351X
Language: English
Faculty: Faculty of Mathematics and Natural Sciences
Divisions: Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HYPOHIDROTIC ECTODERMAL DYSPLASIA; SEVERE LIVER DEGENERATION; ALPHA-INDUCED APOPTOSIS; GAMMA-DEFICIENT MICE; KAPPA-B; EMBRYONIC LETHALITY; GENE-EXPRESSION; CELL-DEATH; C-FLIP; ACTIVATIONMultiple languages
Biochemistry & Molecular BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/28156

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