Er, Fikret, Dahlem, Kristina M., Nia, Amir M., Erdmann, Erland, Waltenberger, Johannes, Hellmich, Martin, Kuhr, Kathrin, Le, Minh Tam, Herrfurth, Tina, Taghiyev, Zulfugar, Biesenbach, Esther, Yueksel, Dilek, Eran-Ergoeknil, Aslihan, Vanezi, Maria, Caglayan, Evren and Gassanov, Natig (2016). Randomized Control of Sympathetic Drive With Continuous Intravenous Esmolol in Patients With Acute ST-Segment Elevation Myocardial Infarction The BEtA-Blocker Therapy in Acute Myocardial Infarction (BEAT-AMI) Trial. JACC-Cardiovasc. Interv., 9 (3). S. 231 - 241. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1876-7605

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Abstract

OBJECTIVES This study sought to evaluate the role of esmolol-induced tight sympathetic control in patients with ST-segment elevation myocardial infarction (STEMI). BACKGROUND Elevated sympathetic drive has a detrimental effect on patients with acute STEMI. The effect of beta-blocker-induced heart rate mediated sympathetic control on myocardial damage is unknown. METHODS The authors conducted a prospective, randomized, single-blind trial involving patients with STEMI and successful percutaneous intervention (Killip class I and II). Patients were randomly allocated to heart rate control with intravenous esmolol for 24 h or placebo. The primary outcome was the maximum change in troponin T release as a prognostic surrogate marker for myocardial damage. A total of 101 patients were enrolled in the study.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Er, FikretUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dahlem, Kristina M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nia, Amir M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erdmann, ErlandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Waltenberger, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hellmich, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuhr, KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Le, Minh TamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herrfurth, TinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taghiyev, ZulfugarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Biesenbach, EstherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yueksel, DilekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eran-Ergoeknil, AslihanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vanezi, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caglayan, EvrenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gassanov, NatigUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-284706
DOI: 10.1016/j.jcin.2015.10.035
Journal or Publication Title: JACC-Cardiovasc. Interv.
Volume: 9
Number: 3
Page Range: S. 231 - 241
Date: 2016
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1876-7605
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PERCUTANEOUS CORONARY INTERVENTION; BRAIN NATRIURETIC PEPTIDE; LEFT-VENTRICULAR FUNCTION; CARDIAC TROPONIN-I; CREATINE KINASE-MB; HEART-RATE CONTROL; PLASMA-CATECHOLAMINES; CLINICAL-OUTCOMES; SERUM BIOMARKERS; PROGNOSTIC VALUEMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/28470

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