Rasche, Andrea ORCID: 0000-0001-6693-1180, de Carvalho Dominguez Souza, Breno Frederico and Drexler, Jan Felix ORCID: 0000-0002-3509-0232 (2016). Bat hepadnaviruses and the origins of primate hepatitis B viruses. Curr. Opin. Virol., 16. S. 86 - 95. OXFORD: ELSEVIER SCI LTD. ISSN 1879-6257

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Abstract

The origin of primate HBV (family Hepadnaviridae) is unknown. Hepadnaviruses are ancient pathogens and may have been associated with old mammalian lineages like bats for prolonged time. Indeed, the genetic diversity of bat hepadnaviruses exceeds that of extant hepadnaviruses in other host orders, suggesting a long evolution of hepadnaviruses in bats. Strikingly, a recently detected New World bat hepadnavirus is antigenically related to HBV and can infect human hepatocytes. Together with genetically diverse hepadnaviruses from New World rodents and a non-human primate, these viruses argue for a New World origin of ancestral orthohepadnaviruses. Multiple host switches of bat and primate viruses are evident and bats are likely sources of ancestral hepadnaviruses acquired by primates.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Rasche, AndreaUNSPECIFIEDorcid.org/0000-0001-6693-1180UNSPECIFIED
de Carvalho Dominguez Souza, Breno FredericoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drexler, Jan FelixUNSPECIFIEDorcid.org/0000-0002-3509-0232UNSPECIFIED
URN: urn:nbn:de:hbz:38-284921
DOI: 10.1016/j.coviro.2016.01.015
Journal or Publication Title: Curr. Opin. Virol.
Volume: 16
Page Range: S. 86 - 95
Date: 2016
Publisher: ELSEVIER SCI LTD
Place of Publication: OXFORD
ISSN: 1879-6257
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
COMPLETE NUCLEOTIDE-SEQUENCE; PAN-TROGLODYTES-TROGLODYTES; ORANGUTANS PONGO-PYGMAEUS; WILD-BORN CHIMPANZEES; NONHUMAN-PRIMATES; PHYLOGENETIC ANALYSIS; CENTRAL-AFRICA; ENDOGENOUS HEPADNAVIRUSES; GENOME CHARACTERIZATION; MOLECULAR EPIDEMIOLOGYMultiple languages
VirologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/28492

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