Universität zu Köln

Mueller, Dennis R., Basso, Fabian, Kurrat, Anne, Soukup, Sebastian T., Niehoff, Anja, Kulling, Sabine E. ORCID: 0000-0002-9956-2702 and Diel, Patrick (2016). Dose-dependent effects of isoflavone exposure during early lifetime on development and androgen sensitivity in male Wistar rats. Mol. Nutr. Food Res., 60 (2). S. 325 - 337. HOBOKEN: WILEY. ISSN 1613-4133

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Abstract

ScopeThe aim of our study was to investigate dose-dependent effects of isoflavone (ISO) exposure during adolescence on the androgen sensitivity of various physiological end points in male Wistar rats. Methods and resultsDuring embryogenesis and adolescence, rats were exposed to an ISO-depleted diet (IDD) or one of two diets enriched with different concentrations of a soy-based ISO extract causing plasma concentrations observed averagely (ISO-rich diet [IRD]low) and maximally (IRDhigh) in Asian men. Most of the rats were orchiectomized at postnatal day (PND) 81 and were treated with testosterone propionate (TP) or vehicle from PND 89 to 99. In intact rats (PND 99) body weight, food intake, and fat mass were not influenced by ISO, but serum triglycerides and hepatic fatty acid synthase expression were decreased. Trabecular bone mineral density (BMD) was reduced in IRDlow, but not in IRDhigh rats. Orchiectomy (ORX) induced loss of BMD, which was antagonized by IRDhigh. ISO increased androgen sensitivity of seminal vesicle and levator ani. Besides, ISO plasma levels were reduced by ORX compared to intact and TP-treated rats. ConclusionIn summary, the results of this study indicate that exposure to ISO during adolescence affects bone homeostasis, lipid metabolism, and modulates androgen sensitivity in young adult male rats.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mueller, Dennis R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Basso, Fabian UNSPECIFIED UNSPECIFIED UNSPECIFIED Kurrat, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Soukup, Sebastian T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Niehoff, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Kulling, Sabine E. UNSPECIFIED orcid.org/0000-0002-9956-2702 UNSPECIFIED Diel, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-285692
DOI:	10.1002/mnfr.201500559
Journal or Publication Title:	Mol. Nutr. Food Res.
Volume:	60
Number:	2
Page Range:	S. 325 - 337
Date:	2016
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1613-4133
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MALE REPRODUCTIVE-TRACT; AGED MALE-RATS; SOY ISOFLAVONES; PROSTATE-CANCER; BONE LOSS; OVARIECTOMIZED RATS; SERUM-CHOLESTEROL; LIPID-METABOLISM; MALE-MICE; GENISTEIN Multiple languages Food Science & Technology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28569