Universität zu Köln

Malter, Michael P., Bahrenberg, Christina, Niehusmann, Pitt, Elger, Christian E. and Surges, Rainer ORCID: 0000-0002-3177-8582 (2016). Features of scalp EEG in unilateral mesial temporal lobe epilepsy due to hippocampal sclerosis: Determining factors and predictive value for epilepsy surgery. Clin. Neurophysiol., 127 (2). S. 1081 - 1088. CLARE: ELSEVIER IRELAND LTD. ISSN 1872-8952

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Abstract

Objective: To investigate determining factors of the ictal scalp EEG pattern at seizure onset and its predictive value for postsurgical outcome in people with unilateral MTLE due to hippocampal sclerosis (MTLE-HS). Methods: Review of consecutive people with chronic MTLE-HS undergoing presurgical video-EEG telemetry. Exclusion criteria were additional epileptogenic lesions or seizure generators or compromised EEG traces at seizure-onset. Mixed linear or logistic regression models were used. Results: Inclusion of 63 patients with 219 seizures with a favorable outcome (no seizures or auras only) in 43 patients at last follow-up. Rhythmic activity at seizure-onset (RA) had a frequency of 4.7 +/- 1.5/s (range 1-8/s), mostly localized in the anterior temporal region. Postsurgical seizure outcome was not associated with any clinical or electrophysiological feature. RA in the delta-band was more often observed with shorter epilepsy duration (p = 0.002). Conclusions: RA on scalp EEG gets faster with increasing epilepsy duration, possibly via time-dependent alterations of epileptogenic networks. Neither the frequency of RA nor other EEG-features appeared to predict postsurgical seizure outcome. Significance: The results challenge the view that if patients with apparent MTLE display RA in the delta-band, seizure-onset in neocortical structures rather than in temporo-mesial tissue should be considered and further investigations should be prompted. (C) 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Malter, Michael P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bahrenberg, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Niehusmann, Pitt UNSPECIFIED UNSPECIFIED UNSPECIFIED Elger, Christian E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Surges, Rainer UNSPECIFIED orcid.org/0000-0002-3177-8582 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-286181
DOI:	10.1016/j.clinph.2015.06.035
Journal or Publication Title:	Clin. Neurophysiol.
Volume:	127
Number:	2
Page Range:	S. 1081 - 1088
Date:	2016
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1872-8952
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SELECTIVE AMYGDALOHIPPOCAMPECTOMY; ICTAL EEG; LOBECTOMY; SEIZURE; PROPAGATION; PATTERNS; CLASSIFICATION; OUTCOMES; FOCI; LOCALIZATION Multiple languages Clinical Neurology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28618