Universität zu Köln

Arzt, Michael, Woehrle, Holger, Oldenburg, Olaf, Graml, Andrea, Suling, Anna, Erdmann, Erland, Teschler, Helmut and Wegscheider, Karl (2016). Prevalence and Predictors of Sleep-Disordered Breathing in Patients With Stable Chronic Heart Failure The SchlaHF Registry. JACC-Heart Fail., 4 (2). S. 116 - 126. OXFORD: ELSEVIER SCI LTD. ISSN 2213-1787

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Abstract

OBJECTIVES This prospective study investigated the prevalence of sleep-disordered breathing (SDB) and its predictors in patients with stable chronic heart failure (HF). BACKGROUND SDB is increasingly recognized as being important in patients with HF. METHODS The multicenter SchlaHF (Sleep-Disordered Breathing in Heart Failure) registry provides demographic and clinical data on chronic, stable, symptomatic patients with HF (New York Heart Association functional class >= II; left ventricular rejection fraction <= 45%). Moderate-to-severe SDB (apnea-hypopnea index <= 15/h) was determined by a 2-channel screening device (ApneaLink, ResMed, Sydney, Australia). RESULTS Data from 6,876 patients were analyzed. The prevalence of moderate-to-severe SDB was 46%, with a significant sex difference: 36% in women (n = 1,448) versus 49% in men (n = 5,428). Prevalence of SDB rose with increasing age (31%, 39%, 45%, 52%, and 59% in those age <= 50, >50 to 60, >60 to 70, >70 to 80, and >80 years, respectively). Risk factors for SDB were body mass index (per 5 units; odds ratio [OR]: 1.29; 95% confidence interval [CI]: 1.22 to 1.36), left ventricular rejection fraction (per 5% decrement from 45%; OR: 1.10; 95% CI: 1.06 to 1.14), age (per 10-year difference to 60 years; OR: 1.41; 95% CI: 1.34 to 1.49), atrial fibrillation (OR: 1.19; 95% CI: 1.06 to 1.34), and male sex (OR: 1.90; 95% CI: 1.67 to 2.17). CONCLUSIONS SchlaHF registry data demonstrate a high prevalence of SDB in a representative population of stable patients with chronic HF receiving contemporary medical management. Male sex, age, body mass index, and the severity of both symptoms and left ventricular dysfunction were clinical predictors for prevalent SOB. (Prevalence, Clinical Characteristics and Type of Sleep-disordered Breathing in Patients With Chronic, Symptomatic, Systolic Heart Failure; NCT01500759) (C) 2016 by the American College of Cardiology Foundation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Arzt, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Woehrle, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Oldenburg, Olaf UNSPECIFIED UNSPECIFIED UNSPECIFIED Graml, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Suling, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Erdmann, Erland UNSPECIFIED UNSPECIFIED UNSPECIFIED Teschler, Helmut UNSPECIFIED UNSPECIFIED UNSPECIFIED Wegscheider, Karl UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-286348
DOI:	10.1016/j.jchf.2015.09.014
Journal or Publication Title:	JACC-Heart Fail.
Volume:	4
Number:	2
Page Range:	S. 116 - 126
Date:	2016
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	2213-1787
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ADAPTIVE SERVO-VENTILATION; CAPILLARY WEDGE PRESSURE; VENTRICULAR DYSFUNCTION; APNEA; POPULATION; APNEALINK(TM); EPIDEMIOLOGY; RATIONALE; MORTALITY; COMMUNITY Multiple languages Cardiac & Cardiovascular Systems Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28634