Schultze-Lutter, Frauke, Debbane, Martin ORCID: 0000-0002-4677-8753, Theodoridou, Anastasia, Wood, Stephen J., Raballo, Andrea ORCID: 0000-0003-3709-4111, Michel, Chantal ORCID: 0000-0003-1165-6681, Schmidt, Stefanie J., Kindler, Jochen ORCID: 0000-0002-9034-2770, Ruhrmann, Stephan ORCID: 0000-0002-6022-2364 and Uhlhaas, Peter J. (2016). Revisiting the Basic Symptom Concept: Toward Translating Risk Symptoms for Psychosis into Neurobiological Targets. Front. Psychiatry, 7. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-0640

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Abstract

In its initial formulation, the concept of basic symptoms (BSs) integrated findings on the early symptomatic course of schizophrenia and first in vivo evidence of accompanying brain aberrations. It argued that the subtle subclinical disturbances in mental processes described as BSs were the most direct self -experienced expression of the underlying neurobiological aberrations of the disease. Other characteristic symptoms of psychosis (e.g., delusions and hallucinations) were conceptualized as secondary phenomena, resulting from dysfunctional beliefs and suboptimal coping styles with emerging BSs and/or concomitant stressors. While BSs can occur in many mental disorders, in particular affective disorders, a subset of perceptive and cognitive BSs appear to be specific to psychosis and are currently employed in two alternative risk criteria. However, despite their clinical recognition in the early detection of psychosis, neurobiological research on the aetiopathology of psychosis with neuroimaging methods has only just begun to consider the neural correlate of BSs. This perspective paper reviews the emerging evidence of an association between BSs and aberrant brain activation, connectivity patterns, and metabolism, and outlines promising routes for the use of BSs in aetiopathological research on psychosis.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schultze-Lutter, FraukeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Debbane, MartinUNSPECIFIEDorcid.org/0000-0002-4677-8753UNSPECIFIED
Theodoridou, AnastasiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wood, Stephen J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raballo, AndreaUNSPECIFIEDorcid.org/0000-0003-3709-4111UNSPECIFIED
Michel, ChantalUNSPECIFIEDorcid.org/0000-0003-1165-6681UNSPECIFIED
Schmidt, Stefanie J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kindler, JochenUNSPECIFIEDorcid.org/0000-0002-9034-2770UNSPECIFIED
Ruhrmann, StephanUNSPECIFIEDorcid.org/0000-0002-6022-2364UNSPECIFIED
Uhlhaas, Peter J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-286947
DOI: 10.3389/fpsyt.2016.00009
Journal or Publication Title: Front. Psychiatry
Volume: 7
Date: 2016
Publisher: FRONTIERS MEDIA SA
Place of Publication: LAUSANNE
ISSN: 1664-0640
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ULTRA-HIGH RISK; SCHIZOPHRENIA SPECTRUM PATIENTS; CLINICAL HIGH-RISK; 1ST-EPISODE SCHIZOPHRENIA; SUBJECTIVE EXPERIENCE; SELF-EXPERIENCE; MENTAL STATES; PSYCHIATRIC-DISORDERS; DOPAMINE SYNTHESIS; DYSFUNCTIONMultiple languages
PsychiatryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/28694

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