Universität zu Köln

Roehr, Susanne ORCID: 0000-0001-9385-0669, Luck, Tobias ORCID: 0000-0001-7551-4397, Heser, Kathrin, Fuchs, Angela, Ernst, Annette, Wiese, Birgitt, Werle, Jochen, Bickel, Horst, Brettschneider, Christian ORCID: 0000-0002-5280-1075, Koppara, Alexander ORCID: 0000-0002-3577-6349, Pentzek, Michael, Lange, Carolin, Prokein, Jana, Weyerer, Siegfried, Moesch, Edelgard, Koenig, Hans-Helmut, Maier, Wolfgang, Scherer, Martin, Jessen, Frank and Riedel-Heller, Steffi G. (2016). Incident Subjective Cognitive Decline Does Not Predict Mortality in the Elderly - Results from the Longitudinal German Study on Ageing, Cognition, and Dementia (AgeCoDe). PLoS One, 11 (1). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Objective Subjective cognitive decline (SCD) might represent the first symptomatic representation of Alzheimer's disease (AD), which is associated with increased mortality. Only few studies, however, have analyzed the association of SCD and mortality, and if so, based on prevalent cases. Thus, we investigated incident SCD in memory and mortality. Methods Data were derived from the German AgeCoDe study, a prospective longitudinal study on the epidemiology of mild cognitive impairment (MCI) and dementia in primary care patients over 75 years covering an observation period of 7.5 years. We used univariate and multivariate Cox regression analyses to examine the relationship of SCD and mortality. Further, we estimated survival times by the KaplanMeier method and case-fatality rates with regard to SCD. Results Among 971 individuals without objective cognitive impairment, 233 (24.0%) incidentally expressed SCD at follow-up I. Incident SCD was not significantly associated with increased mortality in the univariate (HR = 1.0, 95% confidence interval = 0.8-1.3, p = .90) as well as in the multivariate analysis (HR = 0.9, 95% confidence interval = 0.7-1.2, p = .40). The same applied for SCD in relation to concerns. Mean survival time with SCD was 8.0 years (SD = 0.1) after onset. Conclusion Incident SCD in memory in individuals with unimpaired cognitive performance does not predict mortality. The main reason might be that SCD does not ultimately lead into future cognitive decline in any case. However, as prevalence studies suggest, subjectively perceived decline in non-memory cognitive domains might be associated with increased mortality. Future studies may address mortality in such other cognitive domains of SCD in incident cases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Roehr, Susanne UNSPECIFIED orcid.org/0000-0001-9385-0669 UNSPECIFIED Luck, Tobias UNSPECIFIED orcid.org/0000-0001-7551-4397 UNSPECIFIED Heser, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuchs, Angela UNSPECIFIED UNSPECIFIED UNSPECIFIED Ernst, Annette UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiese, Birgitt UNSPECIFIED UNSPECIFIED UNSPECIFIED Werle, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Bickel, Horst UNSPECIFIED UNSPECIFIED UNSPECIFIED Brettschneider, Christian UNSPECIFIED orcid.org/0000-0002-5280-1075 UNSPECIFIED Koppara, Alexander UNSPECIFIED orcid.org/0000-0002-3577-6349 UNSPECIFIED Pentzek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Lange, Carolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Prokein, Jana UNSPECIFIED UNSPECIFIED UNSPECIFIED Weyerer, Siegfried UNSPECIFIED UNSPECIFIED UNSPECIFIED Moesch, Edelgard UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenig, Hans-Helmut UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Scherer, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedel-Heller, Steffi G. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-287305
DOI:	10.1371/journal.pone.0147050
Journal or Publication Title:	PLoS One
Volume:	11
Number:	1
Date:	2016
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MEMORY COMPLAINTS; ASSOCIATION; IMPAIRMENT; SURVIVAL; PEOPLE; RISK; HEALTH; ADULTS; DEATH Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28730