Universität zu Köln

Kopriva, S. and Gigolashvili, T. ORCID: 0000-0002-0416-4796 (2016). Glucosinolate Synthesis in the Context of Plant Metabolism. In: Advances in Botanical Research, S. 99 - 125. LONDON: ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD. ISBN 978-0-12-802883-4; 978-0-08-100327-5

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Abstract

The glucosinolate biosynthesis pathway is an important component of plant secondary metabolism. The transcriptional regulation of this pathway is well described, including the nature of corresponding transcription factors. However, glucosinolate synthesis requires also cofactors and intermediates derived from primary metabolism. In particular the pathway has to be well coordinated with sulphur metabolism, through the donor of activated sulphate, 3'-phosphoadenosine-5'-phosphosulphate (PAPS). The availability of PAPS and other intermediates thus affects the rate of glucosinolate synthesis. Interestingly, very recently three enzymes connected to glucosinolate synthesis have been shown to undergo redox regulation, pointing to the complexity of the control of the pathway. In addition, glucosinolate metabolism is divided across multiple cellular compartments including plastids, cytosol, vacuole, endomembrane structures, as well as mitochondria. Therefore, a suite of transporters are necessary to ensure the exchange of intermediates between the compartments but also to enable the long-distance transport between plant organs and tissues. Here we review our current knowledge on how glucosinolate synthesis is connected to general plant metabolism, on the newly discovered redox regulation of the pathway and on the role of various transporters in glucosinolate biosynthesis and their inter-and intracellular distribution. We believe that these processes hold a key for successful engineering of glucosinolate pathways and improved yield and nutritional properties of crops.

Item Type:	Book Section, Proceedings Item or annotation in a legal commentary
Creators:	Creators Email ORCID ORCID Put Code Kopriva, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gigolashvili, T. UNSPECIFIED orcid.org/0000-0002-0416-4796 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-287865
DOI:	10.1016/bs.abr.2016.07.002
Title of Book:	Advances in Botanical Research
Series Name:	Adv. Bot. Res.
Volume:	80
Page Range:	S. 99 - 125
Date:	2016
Publisher:	ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
Place of Publication:	LONDON
ISSN:	0065-2296
ISBN:	978-0-12-802883-4; 978-0-08-100327-5
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Botanical Institute
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BINDING CASSETTE TRANSPORTER; THYLAKOID ATP/ADP CARRIER; MULTI-PROTEIN FAMILY; ARABIDOPSIS-THALIANA; SECONDARY METABOLITES; SULFUR ASSIMILATION; ADENOSINE-5'-PHOSPHOSULFATE KINASE; TRANSCRIPTION FACTORS; NONHOST RESISTANCE; OXIDATIVE STRESS Multiple languages Plant Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28786