Bey, Katharina, Lennertz, Leonhard, Markett, Sebastian, Petrovsky, Nadine, Gallinat, Juergen, Gruender, Gerhard, Spreckelmeyer, Katja N., Wienker, Thomas F., Mobascher, Arian, Dahmen, Norbert, Thuerauf, Norbert, Kornhuber, Johannes ORCID: 0000-0002-8096-3987, Kiefer, Falk, Toliat, Mohammad R., Nuernberg, Peter, Winterer, Georg and Wagner, Michael ORCID: 0000-0003-2589-6440 (2016). Replication of the association between CHRNA4 rs1044396 and harm avoidance in a large population-based sample. Eur. Neuropsychopharmacol., 26 (1). S. 150 - 156. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1873-7862

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Abstract

Harm avoidance is a personality trait characterized by excessive worrying and fear of uncertainty, which has repeatedly been related to anxiety disorders. Converging lines of research in rodents and humans point towards an involvement of the nicotinic cholinergic system in the modulation of anxiety. Most notably, the rs1044396 polymorphism in the CHRNA4 gene, which codes for the alpha 4 subunit of the nicotinic acetylcholine receptor, has been linked to negative emotionality traits including harm avoidance in a recent study. Against this background, we investigated the association between harm avoidance and the rs1044396 polymorphism using data from N=1673 healthy subjects, which were collected in the context of the German multi-centre study 'Genetics of Nicotine Dependence and Neurobiological Phenotypes'. Homozygous carriers of the C-allele showed significantly higher levels of harm avoidance than homozygous T-allele carriers, with heterozygous subjects exhibiting intermediate scores. The effect was neither modulated by age or gender nor by smoking status. By replicating previous findings in a large population-based sample for the first time, the present study adds to the growing evidence suggesting an involvement of nicotinic cholinergic mechanism in anxiety and negative emotionality, which may pose an effective target for medical treatment. (C) 2015 Elsevier B.V. and ECNP. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bey, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lennertz, LeonhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Markett, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petrovsky, NadineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gallinat, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gruender, GerhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spreckelmeyer, Katja N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wienker, Thomas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mobascher, ArianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dahmen, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thuerauf, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kornhuber, JohannesUNSPECIFIEDorcid.org/0000-0002-8096-3987UNSPECIFIED
Kiefer, FalkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toliat, Mohammad R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nuernberg, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winterer, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDorcid.org/0000-0003-2589-6440UNSPECIFIED
URN: urn:nbn:de:hbz:38-289936
DOI: 10.1016/j.euroneuro.2015.11.007
Journal or Publication Title: Eur. Neuropsychopharmacol.
Volume: 26
Number: 1
Page Range: S. 150 - 156
Date: 2016
Publisher: ELSEVIER SCIENCE BV
Place of Publication: AMSTERDAM
ISSN: 1873-7862
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GENE CHRNA4; POLYMORPHISM; SMOKING; TEMPERAMENT; DEPRESSION; RECEPTORS; MOODMultiple languages
Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; PsychiatryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/28993

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