Kremserova, Silvie, Perecko, Tomas, Soucek, Karel ORCID: 0000-0001-7283-8150, Klinke, Anna, Baldus, Stephan, Eiserich, Jason P. and Kubala, Lukas ORCID: 0000-0002-7729-7338 (2016). Lung Neutrophilia in Myeloperoxidase Deficient Mice during the Course of Acute Pulmonary Inflammation. Oxidative Med. Cell. Longev., 2016. LONDON: HINDAWI LTD. ISSN 1942-0994

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Abstract

Systemic inflammation accompanying diseases such as sepsis affects primarily lungs and induces their failure. This remains the most common cause of sepsis induced mortality. While neutrophils play a key role in pulmonary failure, the mechanisms remain incompletely characterized. We report that myeloperoxidase (MPO), abundant enzyme in neutrophil granules, modulates the course of acute pulmonary inflammatory responses induced by intranasal application of lipopolysaccharide. MPO deficient mice had significantly increased numbers of airway infiltrated neutrophils compared to wild-type mice during the whole course of lung inflammation. This was accompanied by higher levels of RANTES in bronchoalveolar lavage fluid from the MPO deficient mice. Other markers of lung injury and inflammation, which contribute to recruitment of neutrophils into the inflamed lungs, including total protein and other selected proinflammatory cytokines did not significantly differ in bronchoalveolar lavage fluid from the wildtype and the MPO deficient mice. Interestingly, MPO deficient neutrophils revealed a decreased rate of cell death characterized by phosphatidylserine surface expression. Collectively, the importance of MPO in regulation of pulmonary inflammation, independent of its putative microbicidal functions, can be potentially linked to MPO ability to modulate the life span of neutrophils and to affect accumulation of chemotactic factors at the inflammatory site.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kremserova, SilvieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perecko, TomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soucek, KarelUNSPECIFIEDorcid.org/0000-0001-7283-8150UNSPECIFIED
Klinke, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baldus, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eiserich, Jason P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kubala, LukasUNSPECIFIEDorcid.org/0000-0002-7729-7338UNSPECIFIED
URN: urn:nbn:de:hbz:38-290240
DOI: 10.1155/2016/5219056
Journal or Publication Title: Oxidative Med. Cell. Longev.
Volume: 2016
Date: 2016
Publisher: HINDAWI LTD
Place of Publication: LONDON
ISSN: 1942-0994
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NITROTYROSINE FORMATION; APOPTOSIS; ACTIVATION; ACID; RESOLUTION; ONSETMultiple languages
Cell BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/29024

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