Universität zu Köln

Ebrahimi, Ardalan, Gil, Ziv, Amit, Moran, Yen, Tzu-Chen, Liao, Chun-Ta, Chatturvedi, Pankaj, Agarwal, Jaiprakash, Kowalski, Luiz, Kreppel, Matthias, Cernea, Claudio, Brandao, Jose, Bachar, Gideon, Villaret, Andrea Bolzoni, Fliss, Dan, Fridman, Eran, Robbins, K. Thomas, Shah, Jatin ORCID: 0000-0002-6444-6592, Patel, Snehal and Clark, Jonathan ORCID: 0000-0003-1209-772X (2016). Comparison of the American Joint Committee on Cancer N1 versus N2a nodal categories for predicting survival and recurrence in patients with oral cancer: Time to acknowledge an arbitrary distinction and modify the system. Head Neck-J. Sci. Spec. Head Neck, 38 (1). S. 135 - 140. HOBOKEN: WILEY-BLACKWELL. ISSN 1097-0347

Full text not available from this repository.

Abstract

Background. We hypothesized that pathological N1 (pN1) and N2a (pN2a) nodal disease portend a similar prognosis in patients with oral cancer. Methods. An international multicenter study of 739 oral squamous cell carcinoma (SCC) patients with pN1 or pN2a stage disease was conducted. Multivariable analyses were performed using Cox proportional hazard models to compare locoregional failure, disease-specific survival (DSS), and overall survival (OS). Institutional heterogeneity was assessed using 2-stage random effects meta-analysis techniques. Results. Univariate analysis revealed no difference in locoregional failure (p = .184), DSS (p = .761), or OS (p = .475). Similar results were obtained in adjusted multivariable models and no evidence of institutional heterogeneity was demonstrated. Conclusion. The prognosis of pN2a and pN1 disease is similar in oral SCC suggesting these categories could be combined in future revisions of the nodal staging system to enhance prognostic accuracy. However, these results may reflect more aggressive treatment of N2a disease; hence, we caution against using these data to deintensify treatment. (C) 2015 Wiley Periodicals, Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ebrahimi, Ardalan UNSPECIFIED UNSPECIFIED UNSPECIFIED Gil, Ziv UNSPECIFIED UNSPECIFIED UNSPECIFIED Amit, Moran UNSPECIFIED UNSPECIFIED UNSPECIFIED Yen, Tzu-Chen UNSPECIFIED UNSPECIFIED UNSPECIFIED Liao, Chun-Ta UNSPECIFIED UNSPECIFIED UNSPECIFIED Chatturvedi, Pankaj UNSPECIFIED UNSPECIFIED UNSPECIFIED Agarwal, Jaiprakash UNSPECIFIED UNSPECIFIED UNSPECIFIED Kowalski, Luiz UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreppel, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Cernea, Claudio UNSPECIFIED UNSPECIFIED UNSPECIFIED Brandao, Jose UNSPECIFIED UNSPECIFIED UNSPECIFIED Bachar, Gideon UNSPECIFIED UNSPECIFIED UNSPECIFIED Villaret, Andrea Bolzoni UNSPECIFIED UNSPECIFIED UNSPECIFIED Fliss, Dan UNSPECIFIED UNSPECIFIED UNSPECIFIED Fridman, Eran UNSPECIFIED UNSPECIFIED UNSPECIFIED Robbins, K. Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah, Jatin UNSPECIFIED orcid.org/0000-0002-6444-6592 UNSPECIFIED Patel, Snehal UNSPECIFIED UNSPECIFIED UNSPECIFIED Clark, Jonathan UNSPECIFIED orcid.org/0000-0003-1209-772X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-291505
DOI:	10.1002/hed.23871
Journal or Publication Title:	Head Neck-J. Sci. Spec. Head Neck
Volume:	38
Number:	1
Page Range:	S. 135 - 140
Date:	2016
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	1097-0347
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STAGE GROUPINGS; HEAD; NECK; METAANALYSIS; CARCINOMAS Multiple languages Otorhinolaryngology; Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/29150