Aldeyarbi, Hebatalla M. and Karanis, Panagiotis (2016). The Ultra-Structural Similarities between Cryptosporidium parvum and the Gregarines. J. Eukaryot. Microbiol., 63 (1). S. 79 - 86. HOBOKEN: WILEY. ISSN 1550-7408

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Using a transmission electron microscopy-based approach, this study details the striking similarities between Cryptosporidium parvum and the gregarines during in vitro axenic development at high ultra-structural resolution. C. parvum zoites displayed three unusual regions within uninucleated parasites: epimerite-like, protomerite-like, and the cell body; these regions exhibited a high degree of morphological similarity to gregarine-like trophozoites. The presence of a mucron-like bulging structure at the side of the free ovoid gregarine-like zoites was observed after 2 h of cultivation. An irregular pattern of epicytic-like folds were found to cover the surface of the parasites 24 h postcultivation. Some extracellular stages were paired in laterocaudal or side-side syzygy, with the presence of a fusion zone between some of these zoites. The present findings are in agreement with phylogenetic studies that have proposed a sister relationship with gregarines. Cryptosporidium appears to exhibit tremendous variety in cell structure depending on the surrounding environment, thereby mimicking the primitive gregarines in terms of the co-evolution strategy between the parasites and their environments. Given this degree of similarity, different aspects of the evolutionary biology of Cryptosporidium need to be examined, considering the knowledge gained from the study of gregarines.

Item Type: Journal Article
CreatorsEmailORCIDORCID Put Code
URN: urn:nbn:de:hbz:38-291775
DOI: 10.1111/jeu.12250
Journal or Publication Title: J. Eukaryot. Microbiol.
Volume: 63
Number: 1
Page Range: S. 79 - 86
Date: 2016
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1550-7408
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
LIFE-CYCLEMultiple languages
MicrobiologyMultiple languages
Refereed: Yes


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