Universität zu Köln

Liss, B., Cornely, O. A., Hoffmann, D., Dimitriou, V. and Wisplinghoff, H. (2016). 1,3-ss-D-glucan concentrations in blood products predict false positive post-transfusion results. Mycoses, 59 (1). S. 39 - 43. HOBOKEN: WILEY. ISSN 1439-0507

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Abstract

1,3-ss-D-glucan (BDG) is increasingly used to diagnose invasive fungal infections (IFI), although false positive results are a concern. To evaluate the potential interaction of blood products with the BDG assay, human albumin (HA), fresh frozen plasma (FFP), undiluted platelet transfusion (UPT) and packed red blood cells (PRBC) were tested for their BDG content using two different b-D-glucan tests. UPTs tested negative, FFP, PBRC and HA tested positive for BDG. In serial dilution, BDG concentration correlated with blood product concentration. To investigate the clinical impact of blood product transfusions, we measured BDG levels before and after the transfusion in three patients (2 PRBC, 1 HA). In the patients receiving PRBC transfusions, BDG values increased from 13 and 17pgml(-1) to 183 and 361pgml(-1), the HA transfusion increased the serum level from 42 to 58pgml(-1). BDG concentrations measured in blood products can be used to predict false positive BDG results.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Liss, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, O. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dimitriou, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wisplinghoff, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-293112
DOI:	10.1111/myc.12432
Journal or Publication Title:	Mycoses
Volume:	59
Number:	1
Page Range:	S. 39 - 43
Date:	2016
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1439-0507
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INVASIVE FUNGAL-INFECTIONS; BETA-D-GLUCAN; SERUM 1,3-BETA-D-GLUCAN; DIAGNOSIS; CANDIDEMIA; THERAPY; ASSAY; PLASMA Multiple languages Dermatology; Mycology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/29311