Universität zu Köln

Michels, Sebastian and Wolf, Jurgen (2016). Stratified Treatment in Lung Cancer. Oncol. Res. Treat., 39 (12). S. 760 - 767. BASEL: KARGER. ISSN 2296-5262

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Abstract

Even though great efforts have been made to improve chemotherapy-based treatment approaches for lung cancer, the prognosis of patients with advanced and metastasized disease remains particularly poor. In recent years, a growing number of genetic aberrations driving lung cancer have been identified. Targeted inhibition of some of these aberrations, most prominently mutated EGFR and ALK, by tyrosine kinase inhibitors has dramatically increased efficacy and tolerability of systemic lung cancer treatment in subsets of patients. However, the duration of response is limited due to the acquisition of molecular mechanisms of resistance to targeted treatment. Modern next-generation inhibitors aim to break resistance. A deep understanding of the mechanisms of treatment failure is imperative to the development of new approaches. In this review, we focus on the current status of stratified therapy in lung cancer and highlight new, potentially promising treatment approaches. (C) 2016 S. Karger GmbH, Freiburg

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Michels, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolf, Jurgen UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-293254
DOI:	10.1159/000453406
Journal or Publication Title:	Oncol. Res. Treat.
Volume:	39
Number:	12
Page Range:	S. 760 - 767
Date:	2016
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	2296-5262
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RANDOMIZED PHASE-III; OVERCOMES CRIZOTINIB RESISTANCE; CISPLATIN PLUS GEMCITABINE; GENE COPY NUMBER; MET AMPLIFICATION; ALK INHIBITOR; OPEN-LABEL; ROS1 REARRANGEMENTS; ACQUIRED-RESISTANCE; 1ST-LINE TREATMENT Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/29325