Universität zu Köln

Aumailley, Monique ORCID: 0000-0002-4578-0966 (2021). Laminins and interaction partners in the architecture of the basement membrane at the dermal-epidermal junction. Exp. Dermatol., 30 (1). S. 17 - 25. HOBOKEN: WILEY. ISSN 1600-0625

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Abstract

The basement membrane at the dermal-epidermal junction keeps the epidermis attached to the dermis. This anatomical barrier is made up of four categories of extracellular matrix proteins: collagen IV, laminin, nidogen and perlecan. These proteins are precisely arranged in a well-defined architecture through specific interactions between the structural domains of the individual components. Some of the molecular constituents are provided by both fibroblasts and keratinocytes, while others are synthesized exclusively by fibroblasts or keratinocytes. It remains to be determined how the components from the fibroblasts are targeted to the dermal-epidermal junction and correctly organized and integrated with the proteins from the adjacent keratinocytes to form the basement membrane.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Aumailley, Monique UNSPECIFIED orcid.org/0000-0002-4578-0966 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-308245
DOI:	10.1111/exd.14239
Journal or Publication Title:	Exp. Dermatol.
Volume:	30
Number:	1
Page Range:	S. 17 - 25
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-0625
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEPARAN-SULFATE PROTEOGLYCAN; COLLAGEN-IV; ALPHA-1 CHAIN; VII COLLAGEN; BASAL LAMINA; RESTRICTED DISTRIBUTION; EPIDERMOLYSIS-BULLOSA; INTEGRIN-BINDING; GAMMA-2 CHAIN; CELL-ADHESION Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/30824