Ruess, Daniel, Weyer, Vera, Tutunji, Juman, Grau, Stefan, Kocher, Martin, Hoevels, Mauritius, Treuer, Harald, Baues, Christian and Ruge, Maximilian I. (2020). Stereotactic radiosurgery of benign brain tumors in elderly patients: evaluation of outcome and toxicity. Radiat. Oncol., 15 (1). LONDON: BMC. ISSN 1748-717X

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Abstract

Background Stereotactic radiosurgery (SRS) is widely accepted as a therapeutic option for meningiomas (M) and vestibular schwannomas (VS). However, data on outcome and toxicity in the elderly population have rarely been reported in detail. Methods All patients aged >= 65 years with M or VS who underwent single fraction SRS were included. Patient data were analyzed in terms of clinical tumor control and incidence of early and late treatment related complications, which were graded according to the Common Terminology Criteria for Adverse Events (CTCAE), Results We identified 245 patients with benign brain tumors (129 M and 116 VS, median tumor volume 2.9 ml, range 0.1-28). The median age was 71 years (range 65-86) and the mean follow-up times were 42 months (range 2-181). Tumors were irradiated with a median dose of 12.4 Gy. Actuarial clinical and radiological tumor control rates at 2, 5, and 10 years after SRS were 98%, 93%, and 88%, respectively. Recurrent tumors after previous treatment had a higher probability of post-radiosurgical progression (p < 0.001). Permanent toxicity (CTCAE I/II) were noted in 5.7%. No severe adverse events were observed during early and late follow up, although patients > 70 years had a slightly higher risk for toxicity (p = 0.027). The presence and extent of co-morbidities had no significant influence on local tumor control or toxicity. Conclusion SRS provides favorable tumor control with low risk for treatment-related severe complications. Thus, SRS should always be considered as treatment option for benign intracranial tumors (meningiomas, schwannomas), especially in the group of elderly patients.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ruess, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weyer, VeraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tutunji, JumanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grau, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kocher, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoevels, MauritiusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Treuer, HaraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baues, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruge, Maximilian I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-308463
DOI: 10.1186/s13014-020-01714-0
Journal or Publication Title: Radiat. Oncol.
Volume: 15
Number: 1
Date: 2020
Publisher: BMC
Place of Publication: LONDON
ISSN: 1748-717X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GAMMA-KNIFE SURGERY; INTRACRANIAL MENINGIOMA; RESECTION; RISKMultiple languages
Oncology; Radiology, Nuclear Medicine & Medical ImagingMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/30846

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