Nettersheim, Felix Sebastian, De Vore, Lauren and Winkels, Holger (2020). Vaccination in Atherosclerosis. Cells, 9 (12). BASEL: MDPI. ISSN 2073-4409

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Abstract

Atherosclerosis is the major underlying pathology of cardiovascular diseases that together are the leading cause of death worldwide. The formation of atherosclerotic plaques is driven by chronic vascular inflammation. Although several risk factors have been identified and significant progress in disease prevention and treatment has been made, no therapeutic agents targeting inflammation are clinically available. Recent clinical trials established the potential of anti-inflammatory therapies as a treatment of atherosclerosis. However, adverse impacts on host defense have raised safety concerns about these therapies. Scientific evidence during the past 40 years implicated an adaptive immune response against plaque-associated autoantigens in atherogenesis. Preclinical data have underscored the protective potential of immunization against such targets precisely and without the impairment of host defense. In this review, we discuss the current vaccination strategies against atherosclerosis, supposed mechanisms of action, therapeutic potential, and the challenges that must be overcome in translating this idea into clinical practice.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Nettersheim, Felix SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Vore, LaurenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winkels, HolgerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-309357
DOI: 10.3390/cells9122560
Journal or Publication Title: Cells
Volume: 9
Number: 12
Date: 2020
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2073-4409
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LOW-DENSITY-LIPOPROTEIN; REGULATORY T-CELLS; CORONARY-HEART-DISEASE; OF-FUNCTION MUTATIONS; APOLIPOPROTEIN C-III; NATURAL-KILLER-CELLS; CHLAMYDIA-PNEUMONIAE; B-CELLS; APO-B; REDUCES ATHEROSCLEROSISMultiple languages
Cell BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/30935

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