Universität zu Köln

Li, Mengnan, Knapp, Sina K. and Iden, Sandra (2020). Mechanisms of melanocyte polarity and differentiation: What can we learn from other neuroectoderm-derived lineages? Curr. Opin. Cell Biol., 67. S. 99 - 109. LONDON: CURRENT BIOLOGY LTD. ISSN 1879-0410

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Abstract

Melanocytes are neuroectoderm-derived pigment-producing cells with highly polarized dendritic morphology. They protect the skin against ultraviolet radiation by providing melanin to neighbouring keratinocytes. However, the mechanisms underlying melanocyte polarization and its relevance for diseases remain mostly elusive. Numerous studies have instead revealed roles for polarity regulators in other neuroectoderm-derived lineages including different neuronal cell types. Considering the shared ontogeny and morphological similarities, these lineages may be used as reference models for the exploration of melanocyte polarity, for example, regarding dendrite formation, spine morphogenesis and polarized organelle transport. In this review, we summarize and compare the latest progress in understanding polarity regulation in neuronal cells and melanocytes and project key open questions for future work.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Li, Mengnan UNSPECIFIED UNSPECIFIED UNSPECIFIED Knapp, Sina K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Iden, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-309398
DOI:	10.1016/j.ceb.2020.09.001
Journal or Publication Title:	Curr. Opin. Cell Biol.
Volume:	67
Page Range:	S. 99 - 109
Date:	2020
Publisher:	CURRENT BIOLOGY LTD
Place of Publication:	LONDON
ISSN:	1879-0410
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL POLARITY; NEURAL CREST; ACTIVATION; NOTCH; PAR3; MELANOBLASTS; ORGANIZATION; DIVISION; SIGNALS Multiple languages Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/30939