Steffen, Julia K., Jergas, Hannah, Petry-Schmelzer, Jan N., Dembek, Till A., Thies, Tabea ORCID: 0000-0001-9149-3143, Jost, Stefanie T., Dafsari, Haidar S., Kessler, Josef, Wirths, Jochen, Fink, Gereon R., Visser-Vandewalle, Veerle and Barbe, Michael T. (2020). Thalamic Deep Brain Stimulation in Essential Tremor Plus Is as Effective as in Essential Tremor. Brain Sci., 10 (12). BASEL: MDPI. ISSN 2076-3425

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Abstract

The new essential tremor (ET) classification defined ET-plus (ET-p) as an ET subgroup with additional neurological signs besides action tremor. While deep brain stimulation (DBS) is effective in ET, there are no studies specifically addressing DBS effects in ET-p. 44 patients with medication-refractory ET and thalamic/subthalamic DBS implanted at our center were postoperatively classified into ET and ET-p according to preoperative documentation. Tremor suppression with DBS (stimulation ON vs. preoperative baseline and vs. stimulation OFF), measured via the Fahn-Tolosa-Marin tremor rating scale (TRS), stimulation parameters, and the location of active contacts were compared between patients classified as ET and ET-p. TRS scores at baseline were higher in ET-p. ET-p patients showed comparable tremor reduction as patients with ET, albeit higher stimulation parameters were needed in ET-p. Active electrode contacts were located more dorsally in ET-p of uncertain reason. Our data show that DBS is similarly effective in ET-p compared to ET. TRS scores were higher in ET-p preoperatively, and higher stimulation parameters were needed for tremor reduction compared to ET. The latter may be related to a more dorsal location of active electrode contacts in the ET-p group of this cohort. Prospective studies are warranted to investigate DBS in ET-p further.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Steffen, Julia K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jergas, HannahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petry-Schmelzer, Jan N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dembek, Till A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thies, TabeaUNSPECIFIEDorcid.org/0000-0001-9149-3143UNSPECIFIED
Jost, Stefanie T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dafsari, Haidar S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kessler, JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wirths, JochenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, Gereon R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Visser-Vandewalle, VeerleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barbe, Michael T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-309670
DOI: 10.3390/brainsci10120970
Journal or Publication Title: Brain Sci.
Volume: 10
Number: 12
Date: 2020
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2076-3425
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/30967

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