Universität zu Köln

Stastny, Igor, Zubor, Pavol, Kajo, Karol, Kubatka, Peter, Golubnitschaja, Olga and Dankova, Zuzana (2020). Aberrantly Methylated cfDNA in Body Fluids as a Promising Diagnostic Tool for Early Detection of Breast Cancer. Clin. Breast Cancer, 20 (6). S. E711 - 12. DALLAS: CIG MEDIA GROUP, LP. ISSN 1938-0666

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Abstract

Breast malignancies are the leading type of cancer among women. Its prevention and early detection, particularly in young women, remains challenging. To this end, cell-free DNA (cfDNA) detected in body fluids demonstrates great potential for early detection of tissue transformation and altered molecular setup, such as epigenetic profiles. Aberrantly methylated cfDNA in body fluids could therefore serve as a potential diagnostic and prognostic tool in breast cancer management. Abnormal methylation may lead to both an activation of oncogenes via hypomethylation and an inactivation of tumor suppressor genes by hypermethylation. We update the state of the art in the area of aberrant cfDNA methylation analyses as a diagnostic and prognostic tool in breast cancer, report on the main technological challenges, and provide an outlook for advancing the overall management of breast malignancies based on cfDNA as a target for diagnosis and tailored therapies. (C) 2020 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stastny, Igor UNSPECIFIED UNSPECIFIED UNSPECIFIED Zubor, Pavol UNSPECIFIED UNSPECIFIED UNSPECIFIED Kajo, Karol UNSPECIFIED UNSPECIFIED UNSPECIFIED Kubatka, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Golubnitschaja, Olga UNSPECIFIED UNSPECIFIED UNSPECIFIED Dankova, Zuzana UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-309753
DOI:	10.1016/j.clbc.2020.05.009
Journal or Publication Title:	Clin. Breast Cancer
Volume:	20
Number:	6
Page Range:	S. E711 - 12
Date:	2020
Publisher:	CIG MEDIA GROUP, LP
Place of Publication:	DALLAS
ISSN:	1938-0666
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL-FREE-DNA; CIRCULATING TUMOR DNA; LIQUID BIOPSY; PROMOTER METHYLATION; EPIGENETIC MODIFICATIONS; FLAMMER SYNDROME; FIELD GUIDE; PLASMA DNA; SERUM DNA; GENOME Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/30975