Universität zu Köln

Kalbe, Elke, Folkerts, Ann-Kristin, Ophey, Anja, Eggers, Carsten, Elben, Saskia, Dimenshteyn, Karina, Sulzer, Patricia, Schulte, Claudia, Schmidt, Nele, Schlenstedt, Christian ORCID: 0000-0002-3838-6848, Berg, Daniela ORCID: 0000-0001-5796-5442, Witt, Karsten, Wojtecki, Lars and Liepelt-Scarfone, Inga (2020). Enhancement of Executive Functions but Not Memory by Multidomain Group Cognitive Training in Patients with Parkinson's Disease and Mild Cognitive Impairment: A Multicenter Randomized Controlled Trial. Parkinsons Dis., 2020. LONDON: HINDAWI LTD. ISSN 2042-0080

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Abstract

Background. Meta-analyses have demonstrated cognitive training (CT) benefits in Parkinson's disease (PD) patients. However, the patients' cognitive status has only rarely been based on established criteria. Also, prediction analyses of CT success have only sparsely been conducted. Objective. To determine CT effects in PD patients with mild cognitive impairment (PD-MCI) on cognitive and noncognitive outcomes compared to an active control group (CG) and to analyze CT success predictors. Methods. Sixty-four PD-MCI patients (age: 67.61 +/- 7.70; UPDRS-III: 26.58 +/- 13.54; MoCA: 24.47 +/- 2.78) were randomized to either a CT group or a low-intensity physical activity CG for six weeks (twice weekly, 90 minutes). Outcomes were assessed before and after training. MANOVAs with follow-up ANOVAs and multiple regression analyses were computed. Results. Both interventions were highly feasible (participation, motivation, and evaluation); the overall dropout rate was 4.7%. Time x group interaction effects favoring CT were observed for phonemic fluency as a specific executive test (p=0.018, eta(2)(p)=0.092) and a statistical trend for overall executive functions (p=0.095, eta(2)(p)=0.132). A statistical trend for a time x group interaction effect favoring CG was shown for the digit span backward as a working memory test (p=0.098, eta(2)(p)=0.043). Regression analyses revealed cognitive baseline levels, education, levodopa equivalent daily dose, motor scores, and ApoE status as significant predictors for CT success. Conclusions. CT is a safe and feasible therapy option in PD-MCI, yielding executive functions improvement. Data indicate that vulnerable individuals may show the largest cognitive gains. Longitudinal studies are required to determine whether CT may also attenuate cognitive decline in the long term. This trial is registered with DRKS00010186.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kalbe, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Folkerts, Ann-Kristin UNSPECIFIED UNSPECIFIED UNSPECIFIED Ophey, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Eggers, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Elben, Saskia UNSPECIFIED UNSPECIFIED UNSPECIFIED Dimenshteyn, Karina UNSPECIFIED UNSPECIFIED UNSPECIFIED Sulzer, Patricia UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulte, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Nele UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlenstedt, Christian UNSPECIFIED orcid.org/0000-0002-3838-6848 UNSPECIFIED Berg, Daniela UNSPECIFIED orcid.org/0000-0001-5796-5442 UNSPECIFIED Witt, Karsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Wojtecki, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Liepelt-Scarfone, Inga UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-310561
DOI:	10.1155/2020/4068706
Journal or Publication Title:	Parkinsons Dis.
Volume:	2020
Date:	2020
Publisher:	HINDAWI LTD
Place of Publication:	LONDON
ISSN:	2042-0080
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUALITY-OF-LIFE; VERBAL FLUENCY; EFFICACY; INTERVENTIONS; METAANALYSIS; IMPACT; MCI Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31056