Universität zu Köln

Zopfs, D., Rinneburger, M., Pinto dos Santos, D., Reimer, R. P., Laukamp, K. R., Maintz, D., Lennartz, S. and Grosse Hokamp, N. . Evaluating anemia using contrast-enhanced spectral detector CT of the chest in a large cohort of 522 patients. Eur. Radiol.. NEW YORK: SPRINGER. ISSN 1432-1084

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Abstract

Objectives The blood of patients with anemia demonstrates distinctly lower attenuation in unenhanced CT images. However, the frequent usage of intravenous contrast hampers evaluation of anemia. Spectral detector computed tomography (SDCT) allows for reconstruction of virtual non-contrast images (VNC) from contrast-enhanced data (CE). The purpose of this study was to evaluate whether VNC allow for prediction of anemia. Methods Five hundred twenty-two patients with CE-SDCT of the chest and accessible serum hemoglobin (HbS) were retrospectively included. Patients were assigned to three groups (severe anemia, moderate/mild anemia, and healthy) based on recent lab tests (<= 7 days) for HbS following gender and the WHO definition of anemia. CT attenuation was determined using two ROI in the left ventricular lumen and one ROI in the descending thoracic aorta. ROI were placed on CE and copied to VNC. ANOVA, linear regression, and receiver operating characteristics were used for statistic evaluation. Results Average HbS was 11.6 +/- 2.4 g/dl. Attenuation on VNC showed significant differences between healthy patients, patients with mild/moderate anemia, and severely anemic patients (all p <= 0.05). Applying cutoffs of 39.2/37.6 HU and 33.6/32.7 HU allowed to differentiate between healthy, mild/moderately, and severely anemic men/women (AUC 0.857/0.833 and 0.879/0.932). A linear relationship between HbS and attenuation on VNC was established (r(2) = 0.54, HbS = - 0.875 + 0.329 x HU). Conclusions An approximation of HbS and presence of anemia can be conducted based on simple attenuation measurements in contrast-enhanced SDCT examinations enabled by VNC imaging.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zopfs, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rinneburger, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pinto dos Santos, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reimer, R. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Laukamp, K. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lennartz, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grosse Hokamp, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-310788
DOI:	10.1007/s00330-020-07497-y
Journal or Publication Title:	Eur. Radiol.
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1084
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VIRTUAL NON-CONTRAST; UNENHANCED COMPUTED-TOMOGRAPHY; ATTENUATION VALUES; DIAGNOSIS Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31078