Krummholz, Andrea, Gottschalk, I., Geipel, A., Herberg, U., Berg, C., Gembruch, U. and Hellmund, A. . Prenatal diagnosis, associated findings and postnatal outcome in fetuses with congenitally corrected transposition of the great arteries. Arch. Gynecol. Obstet.. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-0711

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Abstract

Purpose To analyze anatomic features and associated malformations in 37 prenatally detected cases of congenitally corrected transposition of the great arteries (ccTGA) and to evaluate the prenatal course, neonatal outcome and mid-term follow-up. Methods Retrospective analysis of prenatal ultrasound of 37 patients with ccTGA in two tertiary centers between 1999 and 2019. All fetuses received fetal echocardiography and a detailed anomaly scan. Postnatal outcome and follow-up data were retrieved from pediatric reports. Results Isolated ccTGA without associated cardiac anomalies was found in 13.5% (5/37), in all other fetuses additional defects such as VSD (73.0%), pulmonary obstruction (35.1%), tricuspid valve anomalies (18.9%), aortic arch anomalies (13.5%), ventricular hypoplasia (5.4%) or atrioventricular block (5.4%) were present. The rate of extracardiac malformations or chromosomal aberrations was low. There were 91.9% (34/37) live births and postnatal survival rates reached 91.2% in a mean follow-up time of 4.98 years. The prenatal diagnosis of ccTGA was confirmed postnatally in all but one documented live birth and the prenatal counselling regarding the expected treatment after birth (uni- versus biventricular repair) was reassured in the majority of cases. The postnatal intervention rate was high, 64.7% (22/34) received surgery, the intervention-free survival was 36.7%, 35.0% and 25.0% at 1 month, 1 year and 10 years, respectively. Conclusions ccTGA is a rare heart defect often associated with additional heterogeneous cardiac anomalies that can be diagnosed prenatally. The presented study demonstrates a favorable outcome in most cases but the majority of patients require surgical treatment early in life.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Krummholz, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gottschalk, I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Geipel, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herberg, U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berg, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gembruch, U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hellmund, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-311002
DOI: 10.1007/s00404-020-05886-8
Journal or Publication Title: Arch. Gynecol. Obstet.
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1432-0711
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HEART; PREVALENCE; OPERATION; FEATURES; REPAIRMultiple languages
Obstetrics & GynecologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31100

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